Caldwell J E, Braidwood J M, Simpson D S
Br J Anaesth. 1985 Aug;57(8):765-9. doi: 10.1093/bja/57.8.765.
Vecuronium bromide 70 micrograms kg-1 was used to facilitate tracheal intubation and provide neuromuscular blockade in 52 patients undergoing laparoscopic sterilization. Anaesthesia was maintained with 67% nitrous oxide in oxygen. Patients were monitored clinically and by tactile assessment of the evoked response of the adductor pollicis to a supramaximal train-of-four stimulation. Intubating conditions were assessed at 90 s in the first 33 patients, and were poor. They improved significantly in the subsequent 19 patients when intubation was delayed until 150 s (P less than 0.05). Operating conditions were good in all except two patients. Residual neuromuscular blockade was antagonized rapidly at completion of surgery by neostigmine 2.5 mg i.v., which was administered provided there was at least one twitch response. The mean duration of the procedure was 14.3 min (SD 2.5 min). The mean time from injection of neostigmine to satisfactory spontaneous breathing and neuromuscular recovery was 1.6 min (SD 0.7 min).
在52例接受腹腔镜绝育术的患者中，使用溴化维库溴铵70微克/千克以辅助气管插管并提供神经肌肉阻滞。麻醉维持采用67%氧化亚氮与氧气混合。对患者进行临床监测，并通过触觉评估拇内收肌对超强四个成串刺激的诱发反应。在前33例患者中，于90秒时评估插管条件，结果较差。在随后的19例患者中，当插管延迟至150秒时，插管条件显著改善（P小于0.05）。除两名患者外，所有患者的手术条件良好。手术结束时，若至少有一次抽搐反应，则静脉注射新斯的明2.5毫克，可迅速拮抗残余神经肌肉阻滞。该手术的平均时长为14.3分钟（标准差2.5分钟）。从注射新斯的明到实现满意的自主呼吸和神经肌肉恢复的平均时间为1.6分钟（标准差0.7分钟）。
