小儿麻醉中维库溴铵（Org NC 45）的评估。

An evaluation of Org NC 45 (vecuronium) in paediatric anaesthesia.

作者信息

Ferres C J, Crean P M, Mirakhur R K

出版信息

Anaesthesia. 1983 Oct;38(10):943-7. doi: 10.1111/j.1365-2044.1983.tb12023.x.

DOI:10.1111/j.1365-2044.1983.tb12023.x

Abstract

Vecuronium (Org NC 45) was evaluated as a neuromuscular blocking agent in children and compared with pancuronium in a double-blind study. Satisfactory intubating conditions were present 90 seconds after 0.1 mg/kg of either drug. The onset of complete block was quicker after vecuronium but the greatest difference was found in the duration to 25% recovery which was significantly shorter with vecuronium (20 min) compared with pancuronium (48 min). The use of vecuronium was associated with cardiovascular stability and no clinical evidence of histamine release. Antagonism of the block was readily achieved with neostigmine.

摘要

在一项双盲研究中，对维库溴铵（Org NC 45）作为儿童神经肌肉阻滞剂进行了评估，并与泮库溴铵进行了比较。给予0.1mg/kg这两种药物中的任何一种后90秒，均出现了满意的插管条件。维库溴铵给药后完全阻滞的起效更快，但在恢复至25%的持续时间上差异最大，与泮库溴铵（48分钟）相比，维库溴铵（20分钟）明显更短。使用维库溴铵与心血管稳定性相关，且无组胺释放的临床证据。新斯的明很容易实现对阻滞的拮抗作用。