Department of Internal Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Department of Internal Medicine, Division of Gastroenterology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Turk J Med Sci. 2017 Jun 12;47(3):947-953. doi: 10.3906/sag-1611-66.
BACKGROUND/AIM: Albumin is the most important protein synthesized by the liver. Posttranscriptional changes occur in the molecular structure of albumin due to various factors and isoforms arise. Ischemic modified albumin (IMA) is one such isoform. This study was conducted to evaluate serum IMA concentrations in patients with hepatitis B virus (HBV)-related chronic liver diseases.
This study included 74 treatment-naive chronic hepatitis B patients, 25 patients with HBV-related cirrhosis, and 49 healthy controls. Serum IMA concentration was measured spectrophotometrically using the albumin cobalt binding test.
The mean IMA concentrations in the chronic hepatitis B group and healthy controls were 0.33 ± 0.11 ABSU and 0.27 ± 0.70 ABSU, respectively, and the difference was statistically significant (P < 0.001). Mean IMA/albumin ratios (IMAR) in the chronic hepatitis B and control groups were 0.08 ± 0.04 and 0.06 ± 0.17, respectively, and the difference was also statistically significant (P < 0.001). Higher serum IMA concentrations and IMAR were detected in patients with advanced fibrosis.
Serum IMA concentration and IMAR are increased in patients with HBV-related chronic liver diseases and IMA and IMAR are associated with the degree of liver fibrosis. IMA and IMAR may have potential use as noninvasive markers of fibrosis in chronic hepatitis B patients.
背景/目的：白蛋白是肝脏合成的最重要的蛋白质。由于各种因素，白蛋白的分子结构会发生转录后变化，从而产生不同的异构体。缺血修饰白蛋白（IMA）就是这样的一种异构体。本研究旨在评估乙型肝炎病毒（HBV）相关慢性肝病患者血清 IMA 浓度。
本研究纳入了 74 例初治慢性乙型肝炎患者、25 例 HBV 相关肝硬化患者和 49 名健康对照者。使用白蛋白钴结合试验分光光度法测定血清 IMA 浓度。
慢性乙型肝炎组和健康对照组的 IMA 平均浓度分别为 0.33±0.11 ABSU 和 0.27±0.70 ABSU，差异有统计学意义（P<0.001）。慢性乙型肝炎组和对照组的 IMA/白蛋白比值（IMAR）分别为 0.08±0.04 和 0.06±0.17，差异也有统计学意义（P<0.001）。纤维化程度较高的患者血清 IMA 浓度和 IMAR 较高。
HBV 相关慢性肝病患者血清 IMA 浓度和 IMAR 升高，IMA 和 IMAR 与肝纤维化程度相关。IMA 和 IMAR 可能成为慢性乙型肝炎患者纤维化的非侵入性标志物。
