谷氨酸单钠对新生大鼠行为和神经化学影响的研究。
Investigation of the behavioral and neurochemical effects of monosodium glutamate on neonatal rats.
机构信息
Department of Medical Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Department of Biology, Faculty of Science and Letters, Pamukkale University, Denizli, Turkey.
出版信息
Turk J Med Sci. 2017 Jun 12;47(3):1002-1011. doi: 10.3906/sag-1511-92.
BACKGROUND/AIM: The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period.
MATERIALS AND METHODS
In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method.
RESULTS
Considering the results of the behavioral test, when we compared the test values of the control group with the values of the MSG-injected groups we noted that there were significant differences in the statistical figures obtained. Additionally, we found that the statistical figures of some neurochemical parameters were also significantly different when we compared the values of the MSG group with the control values.
CONCLUSION
MSG injection has a clear effect on the neurochemical parameters, learning memory, and locomotor activities of rats.
背景/目的：本研究旨在探讨和分析新生期雄性 Wistar 大鼠不同剂量单谷氨酸钠（MSG）注射后的行为和神经化学效应。
材料和方法
为了确定 MSG 的行为和神经化学效应，该实验在新生雄性 Wistar 大鼠上进行，并对不同剂量的 MSG 进行了重复测试。实验完成后，还使用 ELISA 法测量断头大鼠脑细胞中多巴胺、GABA、儿茶酚胺（多巴胺、去甲肾上腺素和肾上腺素）和谷氨酸的水平。
结果
考虑到行为测试的结果，当我们将对照组的测试值与注射 MSG 组的测试值进行比较时，我们注意到所获得的统计数据存在显著差异。此外，我们还发现，当我们将 MSG 组的值与对照组的值进行比较时，一些神经化学参数的统计数据也存在显著差异。
结论
MSG 注射对大鼠的神经化学参数、学习记忆和运动活动有明显影响。
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