Legrand Catherine B, Lambert Cécile J, Comblain Fanny V, Sanchez Christelle, Henrotin Yves E
1 Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Institute of Pathology, CHU Sart-Tilman, Liège, Belgium.
2 Department of Physical Therapy and Rehabilitation, Princess Paola Hospital, Vivalia, Marche-en-Famenne, Belgium.
Cartilage. 2017 Jul;8(3):211-233. doi: 10.1177/1947603516656739. Epub 2016 Jul 7.
Objective Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no way to detect the disease at a molecular level, before the appearance of structural changes and symptoms. So an attractive alternative for monitoring OA is the measurement of biochemical markers in blood, urine, or synovial fluid, which could reflect metabolic changes in joint tissue and therefore disease onset and progression. Animal models are relevant to investigate the early stage of OA and metabolic changes occurring in joint tissues. The goal of this narrative review is to summarize the scientific data available in the literature on soluble biomarkers in animal models of OA. Design A literature search was conducted using the PubMed/Medline and Scopus databases between February 1995 and December 2015. All original articles, systematic and narrative reviews published in French or in English were considered. Results We summarized the data of 69 studies and proposed a classification scheme for OA biomarkers in animal studies, largely inspired by the BIPEDS classification. Conclusions Studies about biomarkers and animal models indicate that some markers could be valuable to monitor OA progression and assess therapeutic response in some animal models.
目的 骨关节炎（OA）是成年人群致残的主要原因之一。目前，其诊断主要基于临床检查和标准X线摄影。迄今为止，在结构改变和症状出现之前，尚无方法在分子水平检测该疾病。因此，监测OA的一个有吸引力的替代方法是测量血液、尿液或滑液中的生化标志物，这些标志物可以反映关节组织的代谢变化，进而反映疾病的发生和进展。动物模型有助于研究OA的早期阶段以及关节组织中发生的代谢变化。本叙述性综述的目的是总结文献中关于OA动物模型中可溶性生物标志物的科学数据。 设计 于1995年2月至2015年12月期间使用PubMed/Medline和Scopus数据库进行文献检索。纳入所有以法语或英语发表的原创文章、系统综述和叙述性综述。 结果 我们总结了69项研究的数据，并提出了动物研究中OA生物标志物的分类方案，该方案很大程度上受到BIPEDS分类的启发。 结论 关于生物标志物和动物模型的研究表明，某些标志物可能对监测某些动物模型中的OA进展和评估治疗反应具有重要价值。
