Neri Isabella, Dante Giulia, Pignatti Lucrezia, Salvioli Chiara, Facchinetti Fabio
a Mother-Infant Department , University of Modena and Reggio Emilia , Modena , Italy.
J Matern Fetal Neonatal Med. 2018 Aug;31(16):2105-2108. doi: 10.1080/14767058.2017.1336223. Epub 2017 Jun 15.
The aim of this study is to investigate the safety and efficacy of castor oil to induce labour.
A retrospective observational case control study was conducted over five years. Castor oil was proposed to women referred to the Birth Centre (Castor Oil group (COG)). They were compared to women who chose to be followed by the traditional doctor-led unit (control group (CG)). Castor oil was administered in a 60 ml single dose in 200 ml of warm water. Inclusion criteria were gestational age between 40 and 41 weeks plus premature rupture of membranes between 12 and 18 hours or amniotic fluid index ≤4 or Bishop Score of ≤4 or absence of spontaneous labour over 41 + 4 weeks.
Pharmacological induction of labour was required for 18 women in the COG (45%) and 36 in the CG (90%) (p < .001). The mode of delivery differed significantly between groups: women assuming castor oil showed a higher incidence of vaginal delivery, whereas the incidence of caesarean section was lower in the COG, but no statistical significance was reached.
The use of castor oil is related to a higher probability of labour initiation within 24 hours. Castor oil can be considered a safe non-pharmacological method for labour induction.
本研究旨在探讨蓖麻油引产的安全性和有效性。
进行了一项为期五年的回顾性观察性病例对照研究。向转诊至分娩中心的女性推荐使用蓖麻油（蓖麻油组（COG））。将她们与选择由传统医生主导的科室进行随访的女性（对照组（CG））进行比较。蓖麻油以60毫升单剂量加入200毫升温水中服用。纳入标准为孕龄在40至41周之间，胎膜早破12至18小时，或羊水指数≤4，或Bishop评分≤4，或孕41 + 4周后无自然分娩。
蓖麻油组18名女性（45%）和对照组36名女性（90%）需要药物引产（p <.001）。两组之间的分娩方式有显著差异：服用蓖麻油的女性阴道分娩发生率较高，而蓖麻油组剖宫产发生率较低，但未达到统计学显著性。
使用蓖麻油与24小时内发动分娩的较高概率相关。蓖麻油可被视为一种安全的非药物引产方法。
