Babajafari Siavash, Akhlaghi Masoumeh, Mazloomi Seyed Mohammad, Ayaz Mehdi, Noorafshan Ali, Jafari Peyman, Hojhabrimanesh Abdollah
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Burn Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Burns. 2018 Feb;44(1):140-149. doi: 10.1016/j.burns.2017.05.014. Epub 2017 Jun 12.
The objective was to determine the effect of isolated soy protein (ISP) and flaxseed oil (FO) on inflammatory and oxidative stress indices, acute phase proteins, and wound healing of burn patients.
One hundred eighty-eight patients were assessed for eligibility in this randomized controlled trial. Of these, seventy-three eligible patients (total burn surface area 20-50%) were randomly assigned to 3 isocaloric groups, labeled as control (wheat flour+corn oil (CO)), ISP+FO, and ISP+CO, to receive these nutrients for 3 weeks. We used intention to treat analysis to overcome bias. Because of the large perturbation in water compartments, patients received nutrients from 4th to 25th day of admission. Serum high sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), superoxide dismutase (SOD), ferritin, albumin, and transferrin were measured. The wound area was evaluated by stereological test.
During the 3-week intervention, hs-CRP (-19.4±5.6, -11.7±4.7μg/ml) and ferritin (-83.8±20.5, -80.1±19.6ng/ml) levels changes significantly reduced compared to the control group (P<0.05). MDA level (-0.05±0.21μmol/l) significantly decreased in group A (P<0/05) but was not significant in groups B and control (P>0.05). Albumin level (0.59±0.14, 0.30±0.12g/dl) significantly increased in group A compared to the control group (P<0.05), but no significant relationship was found between other groups (P>0.05). Transferrin level (4.9±3.6, 2.9±5.1g/dl) significantly increased in ISP groups compared to the control (P<0.05). SOD improved in all groups with no significant difference between them (P>0.05). The stereology examination showed significant improvement in wound healing in the ISP groups on days 22 and 25 compared to the control group.
Nutritional supplements with ISP may attenuate post-burn oxidative stress and inflammation, leading to improved wound healing in burn patients. Flaxseed oil may not exert a beneficial effect over the ISP.
本研究旨在确定分离大豆蛋白（ISP）和亚麻籽油（FO）对烧伤患者炎症和氧化应激指标、急性期蛋白及伤口愈合的影响。
在这项随机对照试验中，对188例患者进行了资格评估。其中，73例符合条件的患者（烧伤总面积20%-50%）被随机分为3个等热量组，分别标记为对照组（小麦粉+玉米油（CO））、ISP+FO组和ISP+CO组，接受这些营养素3周。我们采用意向性分析以克服偏倚。由于水分分布的大幅波动，患者在入院第4天至第25天接受营养素。检测血清高敏C反应蛋白（hs-CRP）、丙二醛（MDA）、超氧化物歧化酶（SOD）、铁蛋白、白蛋白和转铁蛋白。通过体视学检测评估伤口面积。
在为期3周的干预期间，与对照组相比，hs-CRP（-19.4±5.6，-11.7±4.7μg/ml）和铁蛋白（-83.8±20.5，-80.1±19.6ng/ml）水平变化显著降低（P<0.05）。A组MDA水平（-0.05±0.21μmol/l）显著降低（P<0.05），但B组和对照组无显著差异（P>0.05）。与对照组相比，A组白蛋白水平（0.59±0.14，0.30±0.12g/dl）显著升高（P<0.05），但其他组之间未发现显著相关性（P>0.05）。与对照组相比，ISP组转铁蛋白水平（4.9±3.6，2.9±5.1g/dl）显著升高（P<0.05）。所有组的SOD均有改善，但组间无显著差异（P>0.05）。体视学检查显示，与对照组相比，ISP组在第22天和第25天伤口愈合有显著改善。
补充ISP营养可能减轻烧伤后的氧化应激和炎症反应，从而改善烧伤患者的伤口愈合。亚麻籽油对ISP可能没有有益作用。
