Barboza R, Chacín J
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;81(2):419-24. doi: 10.1016/0742-8413(85)90031-3.
The effect of phenothiazine antipsychotic drugs on acid secretion was investigated in the isolated toad gastric mucosa. The acid secretory responses induced by maximal doses of histamine, carbachol and theophylline were all inhibited in a similar fashion by chlorpromazine. The ID50 was between 300 and 600 microM. Histamine-stimulated H+ secretion was also inhibited by trifluoperazine. Soluble cyclic AMP-dependent protein kinase activity was not significantly affected by 300 microM chlorpromazine. Microsomal (H+ + K+)-ATPase activity was significantly reduced by chlorpromazine. The results indicate that phenothiazines can inhibit acid secretion in the toad gastric mucosa and that inhibition of the gastric (H+ + K+)-ATPase may be involved in the mechanism of action.
在离体蟾蜍胃黏膜中研究了吩噻嗪类抗精神病药物对胃酸分泌的影响。氯丙嗪以类似方式抑制了最大剂量组胺、卡巴胆碱和茶碱诱导的胃酸分泌反应。半数抑制浓度（ID50）在300至600微摩尔之间。三氟拉嗪也抑制组胺刺激的氢离子分泌。300微摩尔氯丙嗪对可溶性环磷酸腺苷依赖性蛋白激酶活性无显著影响。氯丙嗪显著降低微粒体（氢离子 + 钾离子）-ATP酶活性。结果表明，吩噻嗪类药物可抑制蟾蜍胃黏膜中的胃酸分泌，胃（氢离子 + 钾离子）-ATP酶的抑制可能参与其作用机制。
