Wootton Daniel G, Dickinson Laura, Pertinez Henry, Court Joanne, Eneje Odiri, Keogan Lynne, Macfarlane Laura, Wilks Sarah, Gallagher Jane, Woodhead Mark, Gordon Stephen B, Diggle Peter J
Institute of Infection and Global Health, University of Liverpool, Liverpool, UK
Dept of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Eur Respir J. 2017 Jun 15;49(6). doi: 10.1183/13993003.02170-2016. Print 2017 Jun.
Our aims were to address three fundamental questions relating to the symptoms of community-acquired pneumonia (CAP): Do patients completely recover from pneumonia symptoms? How long does this recovery take? Which factors influence symptomatic recovery?We prospectively recruited patients at two hospitals in Liverpool, UK, into a longitudinal, observational cohort study and modelled symptom recovery from CAP. We excluded patients with cancer, immunosuppression or advanced dementia, and those who were intubated or palliated from admission. We derived a statistical model to describe symptom patterns.We recruited 169 (52% male) adults. Multivariable analysis demonstrated that the time taken to recover to baseline was determined by the initial severity of symptoms. Severity of symptoms was associated with comorbidity and was inversely related to age. The pattern of symptom recovery was exponential and most patients' symptoms returned to baseline by 10 days.These results will inform the advice given to patients regarding the resolution of their symptoms. The recovery model described here will facilitate the use of symptom recovery as an outcome measure in future clinical trials.
我们的目标是解决与社区获得性肺炎（CAP）症状相关的三个基本问题：患者是否能从肺炎症状中完全康复？这种康复需要多长时间？哪些因素会影响症状的恢复？我们在英国利物浦的两家医院前瞻性招募患者，纳入一项纵向观察性队列研究，并对CAP的症状恢复进行建模。我们排除了患有癌症、免疫抑制或晚期痴呆的患者，以及入院时已插管或接受姑息治疗的患者。我们推导了一个统计模型来描述症状模式。我们招募了169名（52%为男性）成年人。多变量分析表明，恢复到基线所需的时间取决于症状的初始严重程度。症状的严重程度与合并症相关，且与年龄呈负相关。症状恢复模式呈指数形式，大多数患者的症状在10天内恢复到基线水平。这些结果将为向患者提供的有关症状缓解的建议提供依据。这里描述的恢复模型将有助于在未来的临床试验中使用症状恢复作为一项结局指标。
