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来自一种内生菌的细胞毒性六肽缩酚酸肽和抗冠状病毒4-羟基-2-吡啶酮

Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic sp.

作者信息

Chang Shanshan, Yan Biying, Chen Yuchuan, Zhao Wuli, Gao Rongmei, Li Yuhuan, Yu Liyan, Xie Yunying, Si Shuyi, Chen Minghua

机构信息

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

出版信息

Front Chem. 2023 Jan 12;10:1106869. doi: 10.3389/fchem.2022.1106869. eCollection 2022.

DOI:10.3389/fchem.2022.1106869
PMID:36712984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9877305/
Abstract

Three new hexadepsipeptides (-), along with beauvericin (), beauvericin D (), and four 4-hydroxy-2-pyridone derivatives (-) were isolated from the endophytic fungus sp. CPCC 400857 that derived from the stem of tea plant. Their structures were determined by extensive 1D and 2D NMR, and HRESIMS analyses. The absolute configuration of hexadepsipeptides were elucidated by the advanced Marfey's method and chiral HPLC analysis. Compounds , and - displayed the cytotoxicity against human pancreatic cancer cell line, AsPC-1 with IC values ranging from 3.45 to 29.69 μM, and and also showed the antiviral activity against the coronavirus (HCoV-OC43) with IC values of 13.33 and 6.65 μM, respectively.

摘要

从茶树茎部来源的内生真菌sp. CPCC 400857中分离出三种新的六元环缩肽（-），以及白僵菌素（）、白僵菌素D（）和四种4-羟基-2-吡啶酮衍生物（-）。通过广泛的一维和二维核磁共振以及高分辨电喷雾电离质谱分析确定了它们的结构。采用先进的马尔费方法和手性高效液相色谱分析阐明了六元环缩肽的绝对构型。化合物、和-对人胰腺癌细胞系AsPC-1显示出细胞毒性，IC值范围为3.45至29.69 μM，并且和对冠状病毒（HCoV-OC43）也显示出抗病毒活性，IC值分别为13.33和6.65 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666e/9877305/57f96b07b676/fchem-10-1106869-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666e/9877305/fdd8af407008/fchem-10-1106869-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666e/9877305/fd5df5c7401e/fchem-10-1106869-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666e/9877305/8ec923a4e1cc/fchem-10-1106869-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666e/9877305/57f96b07b676/fchem-10-1106869-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666e/9877305/fdd8af407008/fchem-10-1106869-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666e/9877305/fd5df5c7401e/fchem-10-1106869-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666e/9877305/8ec923a4e1cc/fchem-10-1106869-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666e/9877305/57f96b07b676/fchem-10-1106869-g004.jpg

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