School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Sci Rep. 2017 Jun 15;7(1):3585. doi: 10.1038/s41598-017-03077-1.
We assessed gene-gene and gene-physical activity interactions of polymorphisms in C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and lymphotoxin α (LTA) genes on lower extremity performance in community-dwelling elders in Taiwan. Five SNPs (rs1205, rs1130864, rs1800947, rs2794520, and rs3093059) of CRP gene, three SNPs (rs909253, rs1041981, and rs2239704) of LTA gene, and three SNPs (rs3093662, rs1800629, and rs1799964) of TNF-α gene of 472 unrelated elders were genotyped. Lower extremity performance included timed up-and-go test (TUG), walking speed, weight-adjusted leg press (waLP), and timed chair stand (TCS). We detected significant interactions between physical activity with CRP rs2794520, rs1205, and rs3093059; LTA rs909253 and rs1041981; and TNF-α rs1799964 for TCS in women after covariate adjustment (all P < 0.05). In men, significant interactions between physical activity with CRP rs2794520, rs1205, and rs3093059; and LTA rs909253 and rs1041981 for TUG; with CRP rs2794520, rs1205, rs1130864, and rs3093059; and LTA rs909253 and rs1041981 for walking speed; and with TNF-α rs3093662 for waLP after covariate adjustment (all P < 0.05). These variants also significantly interacted with physical activity on TCS in women and on walking speed in men. These results show inflammatory genes are involved in lower extremity performance, likely via gene-physical activity interactions.
我们评估了 C 反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和淋巴毒素-α（LTA）基因中多态性的基因-基因和基因-体力活动相互作用，这些多态性与台湾社区老年人下肢功能有关。对 472 名无血缘关系的老年人的 CRP 基因中的 5 个 SNP（rs1205、rs1130864、rs1800947、rs2794520 和 rs3093059）、LTA 基因中的 3 个 SNP（rs909253、rs1041981 和 rs2239704）和 TNF-α 基因中的 3 个 SNP（rs3093662、rs1800629 和 rs1799964）进行了基因分型。下肢功能包括计时起立行走测试（TUG）、行走速度、体重调整腿举（waLP）和计时椅站立测试（TCS）。在调整协变量后，我们在女性中检测到 CRP rs2794520、rs1205 和 rs3093059；LTA rs909253 和 rs1041981；以及 TNF-α rs1799964 与 TCS 之间存在显著的体力活动相互作用（所有 P 值均<0.05）。在男性中，CRP rs2794520、rs1205 和 rs3093059；以及 LTA rs909253 和 rs1041981 与 TUG；CRP rs2794520、rs1205、rs1130864 和 rs3093059；以及 LTA rs909253 和 rs1041981 与行走速度；以及 TNF-α rs3093662 与 waLP 之间存在显著的体力活动相互作用（所有 P 值均<0.05）。在调整协变量后，这些变体也与女性的 TCS 和男性的行走速度存在显著的体力活动相互作用。这些结果表明，炎症基因参与下肢功能，可能是通过基因-体力活动相互作用。
