Faculty of Public Administration, University of Brawijaya, Malang, Indonesia.
Cathie Marsh Institute for Social Research, Manchester, Lancashire, UK.
Age Ageing. 2015 Jul;44(4):610-5. doi: 10.1093/ageing/afv052. Epub 2015 Apr 22.
although recent studies have suggested that inflammation may play an important role in the process of ageing and in the development of disabilities, knowledge about the role of inflammation in physical performance decline among middle-aged and older people in the context of developing countries is limited.
to examine the association between C-reactive protein (CRP) and the activities of daily living (ADL) among middle-aged (40-54 years old) and older (55-96 years old) people in Indonesia.
data from a population-based sample, the Indonesia Family Life Survey (IFLS) 2007, were analysed. The data consist of 1,702 respondents of middle age (40-54 years old) and 2,017 older respondents who had completed information on ADL and CRP.
CRP concentrations in Dried Blood Spot (DBS) specimens were measured, using the validated enzyme-linked immunosorbent assay (ELISA) method. Thirteen items of ADL were used to measure physical performance. A three-level linear model was applied to take advantage of the nested structure of data at the individual level within the household and community levels.
high levels of CRP were significantly associated with lower ADL for middle-aged and older people (P < 0.001). The model was adjusted for co-morbid conditions, health risk factors, medications, depressive symptoms and sociodemographic characteristics.
the significant association between the high level of CRP and lower ADL among older people in Indonesia is in line with earlier studies in the context of developed countries. This study provides an extension in which the significant association was also found in middle-aged people (40-54 years old).
尽管最近的研究表明，炎症可能在衰老过程和残疾发展中起重要作用，但在发展中国家的背景下，关于炎症在中年和老年人身体机能下降中的作用的知识有限。
检验印度尼西亚中年（40-54 岁）和老年（55-96 岁）人群中 C 反应蛋白（CRP）与日常生活活动（ADL）之间的关系。
对基于人群的样本——印度尼西亚家庭生活调查（IFLS）2007 年的数据进行了分析。数据包括 1702 名中年（40-54 岁）和 2017 名老年受访者，他们完成了 ADL 和 CRP 的信息。
使用经过验证的酶联免疫吸附测定（ELISA）法测量 DBS 标本中的 CRP 浓度。采用 13 项 ADL 来衡量身体机能。采用三级线性模型，利用个体层面、家庭层面和社区层面数据的嵌套结构。
CRP 水平较高与中年和老年人 ADL 水平较低显著相关（P < 0.001）。模型调整了合并症、健康风险因素、药物、抑郁症状和社会人口特征。
CRP 水平较高与印度尼西亚老年人 ADL 水平较低之间的显著关联与发达国家的早期研究一致。本研究提供了一个扩展，即在中年人群（40-54 岁）中也发现了这种显著关联。
