Black T E, Healy T E, Pugh N D, Kay B, Harper N J, Petts H V, Sivalingham T
Eur J Anaesthesiol. 1985 Mar;2(1):29-37.
The neuromuscular blocking action of atracurium and vecuronium acting separately and in combination have been compared using the evoked EMG of the adductor pollicis muscle. Dose response curves have been drawn for the drugs given separately and found to be nonparallel (P less than 0.05). Atracurium was calculated to be 5.25 and 4.1 times less potent than vecuronium, ED50 and ED95 respectively. The effect on neuromuscular transmission of a combined medication using equipotent doses of atracurium and vecuronium, determined from the dose response plots, was found to be greater than would be expected by addition of their separate actions. The combination of small doses resulted in significant neuromuscular blockade.
使用拇收肌诱发肌电图，比较了阿曲库铵和维库溴铵单独及联合使用时的神经肌肉阻滞作用。分别绘制了两种药物的剂量反应曲线，发现它们不平行（P<0.05）。计算得出阿曲库铵的效价分别比维库溴铵低5.25倍（ED50）和4.1倍（ED95）。根据剂量反应图确定，使用等效剂量的阿曲库铵和维库溴铵联合用药对神经肌肉传递的影响，大于两者单独作用相加的预期效果。小剂量联合使用会导致显著的神经肌肉阻滞。
