Larijani G E, Gratz I, Minassian S S, Hughes D L, Afshar M, Karayannis B N
Department of Anesthesiology, Medical College of Pennsylvania, Philadelphia.
Pharmacotherapy. 1992;12(4):278-82.
The neuromuscular and cardiovascular effects of intubating doses of pipecuronium 80 micrograms/kg, pancuronium 100 micrograms/kg, atracurium 500 micrograms/kg, and vecuronium 100 micrograms/kg were compared in 62 patients under isoflurane (end-tidal concentration = 0.5-1%) anesthesia. Pipecuronium, pancuronium, and vecuronium had no significant effect on systolic or diastolic blood pressure. In one patient the administration of atracurium resulted in significant hypotension. Heart rate was significantly increased only after the administration of pancuronium. The neuromuscular-blocking effect of pipecuronium and pancuronium appears to be twice as long as that of vecuronium and atracurium. Administration of neostigmine resulted in significantly faster recovery of muscle function in patients receiving vecuronium or atracurium. Although pipecuronium's neuromuscular-blocking effect is similar to that of pancuronium, its lack of cardiovascular effects more closely resembles that of vecuronium.
在62例接受异氟烷（呼气末浓度=0.5-1%）麻醉的患者中，比较了80微克/千克哌库溴铵、100微克/千克潘库溴铵、500微克/千克阿曲库铵和100微克/千克维库溴铵插管剂量对神经肌肉和心血管的影响。哌库溴铵、潘库溴铵和维库溴铵对收缩压或舒张压无显著影响。1例患者使用阿曲库铵后出现显著低血压。仅在使用潘库溴铵后心率显著增加。哌库溴铵和潘库溴铵的神经肌肉阻滞作用似乎是维库溴铵和阿曲库铵的两倍。新斯的明给药使接受维库溴铵或阿曲库铵的患者肌肉功能恢复明显加快。虽然哌库溴铵的神经肌肉阻滞作用与潘库溴铵相似，但其缺乏心血管效应更类似于维库溴铵。
