Bermas Bonnie L, Sammaritano Lisa R
Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 USA.
Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, USA.
Fertil Res Pract. 2015 Aug 27;1:13. doi: 10.1186/s40738-015-0004-3. eCollection 2015.
Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are disorders that commonly impact reproductive aged women.
Both women with RA and SLE have smaller sized families than do controls. In the case of RA factors other than fertility contribute, while in women with SLE there may be diminished ovarian reserve due to cyclophosphamide therapy and advanced maternal age. RA pregnancies can be complicated by preterm birth and small-for-gestational aged infants. SLE pregnancies have higher rates of fetal loss, in particular in those patients with co-existing antiphospholipid syndrome. SLE pregnancies are also more likely to be complicated by pre-eclampsia and hypertension and to result in preterm birth and small-for-gestational aged infants.
Appropriate fertility evaluation and careful pregnancy planning with coordinated obstetrical care help ensure better outcomes in these patient populations.
类风湿关节炎（RA）和系统性红斑狼疮（SLE）是常见于育龄期女性的疾病。
与对照组相比，患RA和SLE的女性家庭规模更小。对于RA患者，除生育能力外的其他因素也有影响，而对于SLE女性，由于环磷酰胺治疗和产妇年龄偏大，卵巢储备功能可能会下降。RA患者怀孕可能会出现早产和小于胎龄儿等并发症。SLE患者怀孕时胎儿丢失率较高，尤其是那些合并抗磷脂综合征的患者。SLE患者怀孕时更易并发子痫前期和高血压，也更易导致早产和小于胎龄儿。
进行适当的生育能力评估，并在产科护理的协调下进行仔细的妊娠计划，有助于确保这些患者群体获得更好的妊娠结局。
