DeMartinis Nicole C, Brown Megan M, Hinds Brian R, Cohen Philip R
School of Medicine, University of California, San Diego.
Department of Dermatology, University of California, San Diego.
Cureus. 2017 May 9;9(5):e1235. doi: 10.7759/cureus.1235.
Plasma cell leukemia is an uncommon, aggressive variant of leukemia that may occur de novo or in association with multiple myeloma. Leukemia cutis is the cutaneous manifestation of leukemia, and indicates an infiltration of the skin by malignant leukocytes or their precursors. Plasma cell leukemia cutis is a rare clinical presentation of leukemia. We present a man who developed plasma cell leukemia cutis in association with multiple myeloma. Cutaneous nodules developed on his arms and legs 50 days following an autologous stem cell transplant. Histopathologic examination showed CD138-positive nodular aggregates of atypical plasma cells with kappa light chain restriction, similar to the phenotype of his myeloma. In spite of systemic treatment of his underlying disease, he died 25 days after the presentation of leukemia cutis. Pub-Med was searched for the following terms: cutaneous plasmacytomas, leukemia cutis, plasma cell leukemia nodules, plasma cell leukemia cutis, and secondary cutaneous plasmacytoma. Papers were reviewed and appropriate references evaluated. Leukemia cutis in plasma cell leukemia patients is an infrequent occurrence. New skin lesions in patients with plasma cell leukemia should be biopsied for pathology and for tissue cultures to evaluate for cancer or infection, respectively. The diagnosis plasma cell leukemia cutis is associated with a very poor prognosis.
浆细胞白血病是一种罕见的侵袭性白血病变体，可原发发生或与多发性骨髓瘤相关。白血病皮肤表现是白血病的皮肤表现，表明恶性白细胞或其前体浸润皮肤。浆细胞白血病皮肤表现是白血病的一种罕见临床表现。我们报告一例与多发性骨髓瘤相关的浆细胞白血病皮肤表现患者。自体干细胞移植50天后，他的手臂和腿部出现皮肤结节。组织病理学检查显示CD138阳性的非典型浆细胞结节性聚集，伴有κ轻链限制，类似于他骨髓瘤的表型。尽管对其基础疾病进行了全身治疗，但他在出现白血病皮肤表现25天后死亡。在PubMed上搜索了以下术语：皮肤浆细胞瘤、白血病皮肤表现、浆细胞白血病结节、浆细胞白血病皮肤表现和继发性皮肤浆细胞瘤。对论文进行了审查并评估了适当的参考文献。浆细胞白血病患者出现白血病皮肤表现的情况并不常见。浆细胞白血病患者出现新的皮肤病变时，应进行活检以进行病理检查和组织培养，分别评估是否存在癌症或感染。诊断为浆细胞白血病皮肤表现与预后非常差相关。
