Prevalence of Human Papilloma Virus in Sinonasal Papilloma in Southern Iranian Population.

STATEMENT OF THE PROBLEM

Sinonasal papilloma (SNP) is a rare benign lesion characterized by high recurrence rate and malignant transformation.

PURPOSE

This study aimed to investigate the prevalence of human papilloma virus (HPV) infection in these lesions in South of Iran.

MATERIALS AND METHOD

In this cross sectional retrospective study, a total of 41 patients, 38 SNP and 3 SNP/Squamous cell carcinoma cases, from 2007 to 2014 were studied. Human papilloma virus (HPV) DNA detection was performed by nested PCR method and positive cases were analyzed for high risk HPV-16 and HPV-18.

RESULTS

HPV was detected in 31.7%; HPV- 16 in 4.9% and HPV 18 was not detected at all. Dysplastic epithelium was detected in 53% that was not associated with HPV. Three cases were accompanied with malignant transformation that HPV genome was detected in only one case and none of them were positive for HPV16 /18 genomic DNA.

CONCLUSION

Current research suggests that HPV may be involved in the development of SNP. But the high risk HPV is not important in malignant transformation. More studies are needed to elucidate the possible etiologic mechanism between HPV, inverted papilloma, and squamous cell carcinoma.