[人乳头瘤病毒与鼻内翻性乳头状瘤关系的Meta分析]

[Meta analysis of the relationship between human papilloma virus and nasal inverted papilloma].

作者信息

Xiao Wu, Liu Shanfeng, Wang Liyin, Li Huimin, Wu Wenwei, Wang Zhenhai

机构信息

Department of Otolaryngology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Jun;27(11):572-6.

PMID:23987003

Abstract

OBJECTIVE

To evaluate the relationship between human papilloma virus (HPV) infection and the occurrence, recurrence and malignant transformation of nasal inverted papilloma (NIP).

METHOD

With comprehensive retrieval of related literature that had been published in databases included Pubmed (1990--2011), Cochrane Library, CNKI (1979-2011), VIP (1989-2011), CBM (1990-2011) and WANFANG Meta-analysis software Rev-Man 5.0 was used to analyze the raw data and to calculate the value of combined odd ratio (OR) and 95% confidence interval (CI).

RESULT

According to Meta-analysis, the occurrence group between HPV and NIP, the OR was 34.44 and 95% CI was 12.96-91.56; the recurrence group, the OR was 3.66 and 95% CI was 1.77-7.56, to the high-risk HPV, the OR was 1.94 and 95% CI was 0.30-12.58; the malignant transformation group, the OR was 1.79 and 95% CI was 0.94-3.40 to the high-risk HPV, the OR was 49.35 and 95% (CI was 0.45-11.23.

CONCLUSION

HPV may play an important role in the occurrence and recurrence of NIP and high-risk HPV was closely related to the progress of NIP.

摘要

目的

评估人乳头瘤病毒（HPV）感染与鼻内翻性乳头状瘤（NIP）的发生、复发及恶变之间的关系。

方法

全面检索Pubmed（1990 - 2011年）、Cochrane图书馆、CNKI（1979 - 2011年）、维普（1989 - 2011年）、中国生物医学文献数据库（1990 - 2011年）及万方数据库中发表的相关文献，运用Rev-Man 5.0软件对原始数据进行分析，并计算合并比值比（OR）及95%可信区间（CI）。

结果

根据Meta分析，HPV与NIP发生组的OR为34.44，95%CI为12.96 - 91.56；复发组的OR为3.66，95%CI为1.77 - 7.56，高危型HPV的OR为1.94，95%CI为0.30 - 12.58；恶变组中，高危型HPV的OR为1.79，95%CI为0.94 - 3.40，总的OR为49.35，95%CI为0.45 - 11.23。