Yamaoki Yudai, Nagata Takashi, Mashima Tsukasa, Katahira Masato
Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.
Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan and Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.
Chem Commun (Camb). 2017 Jul 4;53(52):7056-7059. doi: 10.1039/c7cc03312e. Epub 2017 Jun 16.
For the development of K-responsive RNA aptamers, we proposed a new general strategy that makes use of a G-quadruplex formation in response to K. This is the first report of developing an RNA aptamer that demonstrates ON/OFF switching of its target-binding activity by sensing the addition/removal of K.
为了开发对钾离子（K⁺）有响应的RNA适配体，我们提出了一种新的通用策略，该策略利用了因钾离子而形成的G-四链体结构。这是首次报道开发出一种RNA适配体，它能通过感知钾离子的添加/去除来展示其靶标结合活性的开启/关闭切换。
