Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2101 McGavran Greenberg Hall, CB# 7435, Chapel Hill, NC, 27599, USA.
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
AIDS Behav. 2018 Apr;22(4):1313-1322. doi: 10.1007/s10461-017-1824-4.
Heavy drinking is prevalent among people living with HIV. Studies use tools like patient-reported outcomes (PROs) to quantify alcohol use in a detailed, timely manner. However, if alcohol misuse influences PRO completion, selection bias may result. Our study included 14,145 adult HIV patients (133,036 visits) from CNICS who were eligible to complete PROs at an HIV primary care visit. We compared PRO completion proportions between patients with and without a clinical diagnosis of at-risk alcohol use in the prior year. We accounted for confounding by baseline and visit-specific covariates. PROs were completed at 20.8% of assessed visits. The adjusted difference in PRO completion proportions was -3.2% (95% CI -5.6 to -0.8%). The small association between receipt of an at-risk alcohol use diagnosis and decreased PRO completion suggests there could be modest selection bias in studies using the PRO alcohol measure.
酗酒在 HIV 感染者中很常见。研究使用患者报告的结果（PROs）等工具来详细、及时地量化酒精使用情况。然而，如果酒精滥用影响 PRO 的完成，可能会导致选择偏差。我们的研究纳入了来自 CNICS 的 14145 名成年 HIV 患者（133036 次就诊），他们有资格在 HIV 初级保健就诊时完成 PROs。我们比较了过去一年有和没有临床诊断为高危酒精使用的患者之间 PRO 完成比例。我们通过基线和就诊特异性协变量进行了混杂因素调整。PROs 在评估的就诊中有 20.8%得到了完成。调整后 PRO 完成比例的差异为-3.2%（95%CI-5.6 至-0.8%）。高危酒精使用诊断与 PRO 完成减少之间的微小关联表明，使用 PRO 酒精测量的研究可能存在适度的选择偏差。
