儿童因故意过量服用铁剂继发暴发性肝衰竭而行肝移植术。
Pediatric liver transplantation for fulminant hepatic failure secondary to intentional iron overdose.
作者信息
Lai Joanne, Chu Jaime, Arnon Ronen
机构信息
Division of Gastroenterology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Hepatology, Recanati/Miller Transplantation Institute, Department of Pediatrics, Mount Sinai Hospital, New York, NY, USA.
出版信息
Pediatr Transplant. 2017 Sep;21(6). doi: 10.1111/petr.12994. Epub 2017 Jun 15.
Acute iron poisoning may lead to life-threatening hepatotoxicity. We present the cases of two pediatric patients with hepatotoxicity following intentional iron ingestion that progressed rapidly to fulminant hepatic failure despite treatment with deferoxamine. Liver transplantation was lifesaving in both patients. These cases emphasize the need for a high index of suspicion for iron ingestion, close monitoring for liver toxicity, and timely consideration for liver transplantation.
急性铁中毒可能导致危及生命的肝毒性。我们报告了两名儿科患者的病例，他们在故意摄入铁剂后出现肝毒性，尽管接受了去铁胺治疗，但仍迅速进展为暴发性肝衰竭。肝移植挽救了两名患者的生命。这些病例强调了对铁摄入要有高度的怀疑指数、密切监测肝毒性以及及时考虑肝移植的必要性。
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