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急性铁中毒:暴发性肝衰竭病例。

Acute Iron Poisoning: A Case of Fulminant Hepatic Failure.

机构信息

Department of Anesthesiology, Critical Care Medicine and Emergency. Unidade Local de Saúde de Santo António. Porto. Portugal.

Department of Critical Care Medicine. Unidade Local de Saúde do Alto Minho. Viana do Castelo. Portugal.

出版信息

Acta Med Port. 2024 Jun 3;37(6):470-472. doi: 10.20344/amp.21071.

Abstract

Acute iron poisoning is an exceedingly rare occurrence, mainly when resulting from intentional ingestion in adults. It can lead to multi-organ toxicity and, in severe cases, may evolve into acute liver failure and cardiovascular collapse, which are the main causes of death. The clinical outcome is largely dependent on the amount of elemental iron ingested and the readiness of treatment, which includes support, early intestinal decontamination and deferoxamine. Despite timely intervention, acute liver failure can be life-threatening, with liver transplantation being the only potentially life-saving measure. In this case report, we describe a case of severe acute iron poisoning due to intentional ingestion that led to fulminant liver failure, which was successfully managed with liver transplantation.

摘要

急性铁中毒极为罕见,主要发生于成人故意摄入时。它可导致多器官毒性,在严重情况下,可能发展为急性肝衰竭和心血管崩溃,这是死亡的主要原因。临床结果在很大程度上取决于摄入的元素铁的量和治疗的及时性,包括支持、早期肠道去污和去铁胺。尽管及时干预,急性肝衰竭仍可能危及生命,肝移植是唯一可能救命的措施。在本病例报告中,我们描述了一例因故意摄入导致暴发性肝衰竭的严重急性铁中毒,成功地通过肝移植进行了治疗。

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