Jahanfar Shayesteh, Lim Kenneth, Ovideo-Joekes Eugenia
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J Perinat Med. 2017 Jul 26;45(5):603-611. doi: 10.1515/jpm-2016-0089.
Our purpose was to examine the association between discordant growth and perinatal mortality and morbidity among twins with careful adjustment for maternal confounding factors.
Two cohorts with and without chorionicity data were compared using generalized estimating modeling.
Our population-based dataset consisted of 12,656 individual twins from whom 4% (452/12,656) had≥30% growth discordance. A subgroup of this population with chorionicity information had an incidence of 7.3%≥30% growth discordance. In growth-discordant twins, perinatal mortality and morbidity were higher than concordant pairs (P<0.01). Low Apgar score and perinatal mortality were more frequent in growth-discordant twins compared with growth-concordant ones (all P<0.01).
Birth weight discordance (BWD) places twins at increased risk of perinatal mortality. Growth discordance was also an independent risk factor for lower Apgar score of 5 min less than 5.
我们的目的是在仔细调整母亲混杂因素的情况下，研究双胎生长不一致与围产期死亡率和发病率之间的关联。
使用广义估计模型对有和没有绒毛膜性数据的两个队列进行比较。
我们基于人群的数据集包含12656例个体双胎，其中4%（452/12656）双胎生长不一致≥30%。该人群中有绒毛膜性信息的亚组中，生长不一致≥30%的发生率为7.3%。在生长不一致的双胎中，围产期死亡率和发病率高于生长一致的双胎（P<0.01）。与生长一致的双胎相比，生长不一致的双胎中低Apgar评分和围产期死亡率更常见（均P<0.01）。
出生体重不一致（BWD）使双胎围产期死亡风险增加。生长不一致也是5分钟Apgar评分低于5分的独立危险因素。
