Patavoukas Evangelos, Åberg-Liesaho Josefina, Halvorsen Cecilia Pegelow, Winbladh Birger, Wiberg-Itzel Eva
Department of Obstetrics and Gynecology, Sodersjukhuset, Stockholm, Sweden.
Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, Stockholm, Sweden.
J Perinat Med. 2018 Aug 28;46(6):605-611. doi: 10.1515/jpm-2017-0044.
Lactic acid dehydrogenase (LDH) is a valuable marker for some of the most important diseases in newborns and the plasma LDH activity in newborns correlates well with conditions such as asphyxia. If LDH should be considered as a useful tool also in obstetric care, key factors associated with maternal health before and during pregnancy which could affect umbilical cord LDH activity need to be known. The aims of this study were to explore relationships between selected maternal conditions and arterial lactic acid dehydrogenase activity (aLDH) in umbilical cord blood at delivery.
A prospective observational study was conducted at Sodersjukhuset, Stockholm, Sweden. Included in the study were 1247 deliveries, and cord blood samples from each were analyzed for aLDH. Background, delivery and neonatal data were collected from the medical records.
Higher median values of aLDH were found (P=0.001) among women with chronic disorders not related to pregnancy but there was no increased frequency of high aLDH levels (>612 μ/L, P=0.30). No difference in aLDH was identified between infants born to women with pregnancy-related disorders compared with healthy women, neither in median values, nor in high values (>612 μ/L, P=0.95).
Newborn infants born to women with non-pregnancy-related chronic disorders had a somewhat higher median value of aLDH in cord blood at delivery. The influence of common maternal conditions and diseases on umbilical cord arterial LDH levels is small compared to the increase reported in fetal distress and several other critical conditions in the newborn.
乳酸脱氢酶（LDH）是新生儿一些最重要疾病的重要标志物，新生儿血浆LDH活性与窒息等情况密切相关。如果LDH也应被视为产科护理中的有用工具，那么就需要了解与孕期前后母亲健康相关的可能影响脐带LDH活性的关键因素。本研究的目的是探讨选定的母亲状况与分娩时脐带血中动脉乳酸脱氢酶活性（aLDH）之间的关系。
在瑞典斯德哥尔摩的南泰利耶医院进行了一项前瞻性观察研究。该研究纳入了1247例分娩病例，并对每份脐带血样本进行了aLDH分析。从医疗记录中收集了背景、分娩和新生儿数据。
在患有与妊娠无关的慢性疾病的女性中发现aLDH的中位数较高（P = 0.001），但aLDH水平升高（>612 μ/L）的频率没有增加（P = 0.30）。与健康女性相比，患有与妊娠相关疾病的女性所生婴儿的aLDH在中位数和高值（>612 μ/L）方面均无差异（P = 0.95）。
患有与妊娠无关的慢性疾病的女性所生的新生儿在分娩时脐带血中aLDH的中位数略高。与胎儿窘迫和新生儿其他几种危急情况中报道的升高相比，常见的母亲状况和疾病对脐带动脉LDH水平的影响较小。
