Vermeulen Karlijn, Staal Wouter G, Janzing Joost G, van Bokhoven Hans, Egger Jos I M, Kleefstra Tjitske
*Karakter Child and Adolescent Psychiatry, University Center, †Department of Psychiatry, ‡Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behavior, and §Department of Human Genetics, Radboud University Medical Centre; ∥Centers for Molecular Life Sciences and ¶Cognition, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen; #Center of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray; and **Behavioral Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Clin Neuropharmacol. 2017 Jul/Aug;40(4):185-188. doi: 10.1097/WNF.0000000000000226.
Intellectual disability is frequently accompanied by psychiatric symptoms that require pharmacological interventions. Treatment guidelines often provide a general treatment approach for these symptoms in intellectual disability. However, this may not always be the best strategy, as illustrated here in Kleefstra syndrome. We present 3 patients showing severe regression after sleep disturbances. If these are treated with care as usual (eg, behavioral programs and sleep medication) deterioration is likely to follow. It is observed that rapid treatment with relatively high dosages of antipsychotics contributes to restore sleep, halt further regression, and improve daily life functioning.
智力残疾常常伴有需要药物干预的精神症状。治疗指南通常会针对智力残疾中的这些症状提供一种通用的治疗方法。然而，这可能并不总是最佳策略，如克莱夫斯特拉综合征所示。我们介绍了3例在睡眠障碍后出现严重退化的患者。如果像往常一样谨慎治疗（如行为疗法和睡眠药物），病情可能会恶化。据观察，使用相对高剂量的抗精神病药物进行快速治疗有助于恢复睡眠、阻止进一步退化并改善日常生活功能。
