Bayat Mahdi, Kumar Viksit, Denis Max, Webb Jeremy, Gregory Adriana, Mehrmohammadi Mohammad, Cheong Mathew, Husmann Douglas, Mynderse Lance, Alizad Azra, Fatemi Mostafa
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America.
Department of Radiology, Mayo Clinic, Rochester, MN, United States of America.
PLoS One. 2017 Jun 16;12(6):e0179598. doi: 10.1371/journal.pone.0179598. eCollection 2017.
The objective of this study is to assess correlation between bladder wall mechanical properties obtained by ultrasound bladder vibrometry (UBV) and urodynamic study (UDS) measurements in a group of patients undergoing clinical UDS procedure.
Concurrent UBV and UDS were performed on 70 patients with neurogenic bladders (56 male and 14 female). Bladder wall mechanical properties measured by UBV at different filling volumes were correlated with recorded detrusor pressure (Pdet) values. Mean, median and standard deviation of correlation values were calculated and the significance of these observations was tested.
Bladder wall mechanical properties obtained by UBV as group velocity squared and elasticity showed high correlations with Pdet measured at different volumes (median correlation 0.73, CI: 0.64-0.80 and 0.72, CI: 0.56-0.82 respectively). The correlation of group velocity squared and elasticity with Pdet were both significantly higher than 0.5.
The results of this study suggest that UBV can closely monitor changes in bladder wall mechanical properties at different volumes in a group of patients undergoing UDS. The high correlation between UBV parameters and detrusor pressure measurements suggests that UBV can be utilized as a reliable and cost-effective tool for assessment of the bladder wall mechanical changes in a noninvasive fashion.
本研究的目的是评估在一组接受临床尿动力学检查的患者中，通过超声膀胱振动测量法（UBV）获得的膀胱壁力学特性与尿动力学研究（UDS）测量结果之间的相关性。
对70例神经源性膀胱患者（56例男性和14例女性）同时进行UBV和UDS检查。在不同充盈量下通过UBV测量的膀胱壁力学特性与记录的逼尿肌压力（Pdet）值相关。计算相关值的均值、中位数和标准差，并检验这些观察结果的显著性。
通过UBV获得的膀胱壁力学特性，即群速度平方和弹性，与在不同容量下测量的Pdet显示出高度相关性（中位数相关性分别为0.73，CI：0.64 - 0.80和0.72，CI：0.56 - 0.82）。群速度平方和弹性与Pdet的相关性均显著高于0.5。
本研究结果表明，UBV可以密切监测一组接受UDS检查的患者在不同容量下膀胱壁力学特性的变化。UBV参数与逼尿肌压力测量之间的高度相关性表明，UBV可以作为一种可靠且具有成本效益的工具，以无创方式评估膀胱壁的力学变化。
