纳洛酮可拮抗α-麦醇溶蛋白对乳糜泻患者白细胞迁移的影响。
Naloxone antagonises effect of alpha-gliadin on leucocyte migration in patients with coeliac disease.
作者信息
Horváth K, Gráf L, Walcz E, Bodánszky H, Schuler D
出版信息
Lancet. 1985 Jul 27;2(8448):184-5. doi: 10.1016/s0140-6736(85)91499-0.
PMID:2862373
Abstract
The effect of naloxone on inhibition of leucocyte migration by alpha-gliadin was examined in 24 patients with coeliac disease. In all cases in which alpha-gliadin inhibited leucocyte migration, naloxone blocked this inhibitory effect, which suggests that the effect of gliadin on lymphocytes from patients with coeliac disease may be mediated through opioid-like receptors.
摘要
在24例乳糜泻患者中研究了纳洛酮对α-麦醇溶蛋白抑制白细胞迁移的作用。在所有α-麦醇溶蛋白抑制白细胞迁移的病例中，纳洛酮均能阻断这种抑制作用，这表明麦醇溶蛋白对乳糜泻患者淋巴细胞的作用可能是通过阿片样受体介导的。
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