Graf L, Horvath K, Walcz E, Berzetei I, Burnier J
Neuropeptides. 1987 Feb-Mar;9(2):113-22. doi: 10.1016/0143-4179(87)90050-3.
Two synthetic peptides containing residues 43-47 and 43-49 of alpha-gliadin were tested for inhibition of leukocyte migration in 47 patients with celiac disease. In nineteen patients, all on a normal diet, leukocyte migration was inhibited by the peptides and naloxone blocked this effect. In twenty-eight patients (24 of whom were on strict gluten-free diet) leukocyte migration was not affected by the peptides. Our results suggest that alpha-gliadin-(43-49), Tyr-Pro-Gln-Pro-Gln-Pro-Phe, is closely related to the active fragment, or to one of the active fragments of alpha-gliadin, and that it interacts with receptors that are similar to but not identical with the known opiate receptors.
对含有α-麦醇溶蛋白43 - 47位残基和43 - 49位残基的两种合成肽进行了测试，以观察其对47例乳糜泻患者白细胞迁移的抑制作用。在19例均采用正常饮食的患者中，这些肽可抑制白细胞迁移，且纳洛酮可阻断这种作用。在28例患者中（其中24例采用严格的无麸质饮食），白细胞迁移不受这些肽的影响。我们的结果表明，α-麦醇溶蛋白-（43 - 49），即Tyr-Pro-Gln-Pro-Gln-Pro-Phe，与α-麦醇溶蛋白的活性片段或其中一个活性片段密切相关，并且它与类似于但不同于已知阿片受体的受体相互作用。
