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五规则不应阻碍抗寄生虫药物的研发。

The rule of five should not impede anti-parasitic drug development.

作者信息

McKerrow James H, Lipinski Christopher A

机构信息

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, United States.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, United States.

出版信息

Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):248-249. doi: 10.1016/j.ijpddr.2017.05.003. Epub 2017 May 27.

DOI:10.1016/j.ijpddr.2017.05.003
PMID:28623818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5473536/
Abstract

The "rule of 5" has become a mainstay of decision-making in the pharmaceutical industry as well as in nonindustrial (academic and institutional) drug development. However the authors of the original paper never intended for "double cutoffs" to preclude development of new drug leads for parasitic diseases.

摘要

“5法则”已成为制药行业以及非工业（学术和机构）药物研发决策的主要依据。然而，原始论文的作者从未打算用“双重截断值”来排除抗寄生虫病新药先导物的研发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dd2/5473536/ca174095da59/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dd2/5473536/ca174095da59/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dd2/5473536/ca174095da59/fx1.jpg

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