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MicroRNA-146a-5p Limits Elevated TGF-β Signal during Cell Senescence.

作者信息

Min Seung-Ki, Jung Sung Youn, Kang Hyun Ki, Jo Seung Bin, Kim Myung-Jin, Min Byung-Moo

机构信息

Department of Oral and Maxillofacial Surgery, Seoul National University School of Dentistry, Seoul 03080, Republic of Korea.

Department of Oral Biochemistry and Program in Cancer and Developmental Biology, Dental Research Institute, Seoul National University School of Dentistry, Seoul 03080, Republic of Korea.

出版信息

Mol Ther Nucleic Acids. 2017 Jun 16;7:335-338. doi: 10.1016/j.omtn.2017.04.016. Epub 2017 Apr 22.

DOI:10.1016/j.omtn.2017.04.016
PMID:28624209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5424570/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70ba/5424570/2bb8ba8775b0/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70ba/5424570/2bb8ba8775b0/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70ba/5424570/2bb8ba8775b0/gr1a.jpg

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本文引用的文献

1
MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes.微小RNA-146a负向调节角质形成细胞中Toll样受体2诱导的炎症反应。
J Invest Dermatol. 2014 Jul;134(7):1931-1940. doi: 10.1038/jid.2014.89. Epub 2014 Feb 13.
2
Increased miRNA-146a and miRNA-155 expressions in oral lichen planus.口腔扁平苔藓中 miRNA-146a 和 miRNA-155 的表达增加。
Arch Dermatol Res. 2012 Jul;304(5):371-5. doi: 10.1007/s00403-011-1197-x. Epub 2011 Dec 4.
3
Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis.
用于人类癌症的液体活检：癌症筛查、监测与治疗。
MedComm (2020). 2024 May 28;5(6):e564. doi: 10.1002/mco2.564. eCollection 2024 Jun.
4
Peripheral and tumor-infiltrating immune cells are correlated with patient outcomes in ovarian cancer.外周和肿瘤浸润免疫细胞与卵巢癌患者的预后相关。
Cancer Med. 2023 Apr;12(8):10045-10061. doi: 10.1002/cam4.5590. Epub 2023 Jan 16.
5
Long-Term Decrease of Intraocular Pressure in Rats by Viral Delivery of miR-146a.病毒介导 miR-146a 转染抑制大鼠眼内压长期升高
Transl Vis Sci Technol. 2021 Jul 1;10(8):14. doi: 10.1167/tvst.10.8.14.
6
MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.miR-146a 通过靶向 Coxsackievirus B 感染中的 TLR3 和 TRAF6 下调炎症反应。
RNA. 2020 Jan;26(1):91-100. doi: 10.1261/rna.071985.119. Epub 2019 Nov 1.
胃癌中 miR-146a 的增加直接靶向 SMAD4，并参与调节细胞增殖和凋亡。
Oncol Rep. 2012 Feb;27(2):559-66. doi: 10.3892/or.2011.1514. Epub 2011 Oct 21.
4
MicroRNA miR-146b-5p regulates signal transduction of TGF-β by repressing SMAD4 in thyroid cancer.微小 RNA miR-146b-5p 通过抑制甲状腺癌细胞中的 SMAD4 来调节 TGF-β 的信号转导。
Oncogene. 2012 Apr 12;31(15):1910-22. doi: 10.1038/onc.2011.381. Epub 2011 Aug 29.
5
MicroRNA-146a downregulates NFκB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma.微小 RNA-146a 通过靶向 TRAF6 下调 NFκB 活性，作为一种肿瘤抑制因子，在 NK/T 细胞淋巴瘤中具有强烈的预后意义。
Clin Cancer Res. 2011 Jul 15;17(14):4761-71. doi: 10.1158/1078-0432.CCR-11-0494. Epub 2011 May 24.
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Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling.Bmi-1 通过抑制 TGF-β 信号延长正常人口腔角质细胞的寿命。
Exp Cell Res. 2010 Oct 1;316(16):2600-8. doi: 10.1016/j.yexcr.2010.04.013. Epub 2010 Jul 13.
7
Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1).多个 microRNAs 通过抑制 p21(Waf1/Cip1) 从 Ras 诱导的衰老中恢复。
Oncogene. 2010 Apr 15;29(15):2262-71. doi: 10.1038/onc.2009.497. Epub 2010 Jan 25.
8
Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma.鉴定与口腔白斑病进展为口腔癌相关的 microRNA 特征。
Hum Mol Genet. 2009 Dec 15;18(24):4818-29. doi: 10.1093/hmg/ddp446. Epub 2009 Sep 23.
9
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses.核因子-κB依赖性诱导微小RNA miR-146，一种靶向先天免疫应答信号蛋白的抑制剂。
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6. doi: 10.1073/pnas.0605298103. Epub 2006 Aug 2.
10
Common genes responsible for differentiation and senescence of human mucosal and epidermal keratinocytes.负责人类黏膜和表皮角质形成细胞分化与衰老的常见基因。
Int J Mol Med. 2003 Sep;12(3):319-25.