Ishitani Haruro, Furiya Yuichi, Kobayashi Shū
Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Chemistry, School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Bioorg Med Chem. 2017 Dec 1;25(23):6229-6232. doi: 10.1016/j.bmc.2017.04.017. Epub 2017 Apr 13.
A continuous-flow synthesis of β-nitroolefins by using heterogeneous base catalysts has been developed. Although the use of an excess amount of nitro-donor such as nitromethane is required in conventional methods, nearly equimolar amounts of nitro-donors and carbonyl compounds are sufficient for high-yielding production of nitroolefins. Catalysts for this flow protocol are inexpensive and abundant, and high durability and high productivity were also realized by using an appropriate second support.
已开发出一种使用多相碱催化剂连续流动合成β-硝基烯烃的方法。尽管传统方法需要使用过量的硝基供体（如硝基甲烷），但几乎等摩尔量的硝基供体和羰基化合物就足以高产率地生产硝基烯烃。该流动反应方案的催化剂价格低廉且来源丰富，并且通过使用合适的第二载体还实现了高耐久性和高生产率。
