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[银屑病患者:对治疗不满的患者分析]

[Psoriatic patients: Analysis of patients dissatisfied with their management].

作者信息

Mahé E, Maccari F, Beauchet A, Quiles-Tsimaratos N, Beneton N, Parier J, Barthelemy H, Goujon-Henry C, Chaby G, Thomas-Beaulieu D, Géner G, Wagner L, Pallure V, Devaux S, Vermersch-Langlin A, Pfister P, Jégou J, Livideanu C, Sigal M-L

机构信息

Service de dermatologie, centre hospitalier Victor-Dupouy, 69, rue du Lieutenant-Colonel Prud'hon, 95107 Argenteuil cedex, France.

Service de dermatologie, hôpital d'instruction des armées Bégin, 69, avenue de Paris, 94160 Saint-Mandé, France.

出版信息

Ann Dermatol Venereol. 2017 Aug-Sep;144(8-9):497-507. doi: 10.1016/j.annder.2017.03.025. Epub 2017 Jun 16.

Abstract

BACKGROUND

The French are frequently regarded as grouchy. In a recent study, we observed a high proportion of patients initially consulting for psoriasis because they were dissatisfied with their previous therapy. We analyzed the characteristics of these patients.

PATIENTS AND METHODS

This was a cross-sectional multicenter study in 40 centers belonging to the ResoPso (psoriasis treatment network) multicenter study group, with consecutive inclusions over a period of 11months in 2014. All adults (age>18 years) consulting for the first time for psoriasis at a center were included in the study.

RESULTS

Among patients, 1205 were included, of whom 249 (20.3%) were consulting because of their dissatisfaction with treatment. In the univariate analysis, these patients were younger (P=0.02) and presented psoriasis that had begun earlier in life (P<0.0001). It consisted mostly of generalized plaque psoriasis (P=0.047) and more severe forms of psoriasis (PASI and/or DLQI score>10, P<0.02). There were fewer cases of psoriatic arthritis (P=0.01). The "dissatisfied" patients reported significantly more frequent use of topical treatments (P<0.0001) and alternative medicines (P=0.02), and more infrequent use of biologics (P=0.006) as well as longer treatment periods (P=0.0005). They consulted at hospitals (P=0.01) and had previously seen more GPs and dermatologists (P≤0.0008). There was no impact of gender on the dissatisfaction profile by either comorbidities (metabolic, blood pressure, alcohol and tobacco consumption, and depression), or socio-economic data. In the multivariate analysis, DLQI>10 (P=0.01; 95% CI: 1.01-1.07) and longer duration of care (P=0.004; 95% CI: 1.23-2.99) were associated with dissatisfaction.

CONCLUSION

Twenty percent of our psoriatic patients seem dissatisfied with their treatment. It is difficult to draw a specific demographic and socioeconomic profile of dissatisfied patients. Only disease severity and possibly inadequate treatment at the initial consultation are associated with patient dissatisfaction. Explanations related to the individual patients and doctors may be proposed. Finally, while the French may be considered grouchy, the frequency of patient dissatisfaction seen in our study does not appear to be any greater than that observed in other countries.

摘要

背景

法国人常被认为脾气暴躁。在最近一项研究中,我们观察到很大一部分最初因对先前治疗不满而前来咨询银屑病的患者。我们分析了这些患者的特征。

患者与方法

这是一项横断面多中心研究,在属于ResoPso(银屑病治疗网络)多中心研究组的40个中心进行,于2014年连续纳入患者11个月。所有首次在某中心咨询银屑病的成年人(年龄>18岁)均纳入本研究。

结果

共纳入1205例患者,其中249例(20.3%)因对治疗不满前来咨询。单因素分析显示,这些患者更年轻(P = 0.02),银屑病发病更早(P < 0.0001)。主要为泛发性斑块状银屑病(P = 0.047)以及更严重的银屑病类型(银屑病面积和严重程度指数[PASI]和/或皮肤病生活质量指数[DLQI]评分>10,P < 0.02)。银屑病关节炎病例较少(P = 0.01)。“不满意”的患者报告使用外用治疗(P < 0.0001)和替代药物(P = 0.02)更为频繁,使用生物制剂(P = 0.006)以及治疗时间更长(P = 0.0005)则更为少见。他们在医院就诊(P = 0.01),此前看过更多的全科医生和皮肤科医生(P≤0.0008)。无论是合并症(代谢、血压、烟酒消费及抑郁)还是社会经济数据,性别对不满意情况均无影响。多因素分析显示,DLQI>10(P = 0.01;95%置信区间:1.01 - 1.07)和护理时间更长(P = 0.004;95%置信区间:1.23 - 2.99)与不满意相关。

结论

我们的银屑病患者中20%似乎对治疗不满意。难以勾勒出不满意患者的特定人口统计学和社会经济特征。仅疾病严重程度以及初诊时可能治疗不足与患者不满意相关。可提出与个体患者和医生相关的解释。最后,虽然法国人可能被认为脾气暴躁,但我们研究中观察到的患者不满意频率似乎并不高于其他国家。

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