Kwiatkowska Joanna, Wąsowska Barbara, Gilun Przemysław
Department of Local Physiological Regulations, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.
Department of Local Physiological Regulations, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.
Reprod Biol. 2017 Sep;17(3):289-293. doi: 10.1016/j.repbio.2017.05.013. Epub 2017 Jun 16.
The aim of this study was to determine how 60-min ischemia changes the expression of hypoxia inducible factor 1α (HIF-1α) and superoxide dismutases (SOD)-1 and -2 in selected regions of porcine uterine horns. The results showed that 60-min ischemia of the porcine uterus conducted at the mid-secretory estrous phase caused decreased HIF-1α and increased SOD-2 gene expression. Higher expression of SOD-2 suggests that this enzyme may play an important role in the suppression of HIF-1α accumulation in an ischemic endometrium.
本研究的目的是确定60分钟的局部缺血如何改变猪子宫角选定区域中缺氧诱导因子1α（HIF-1α）以及超氧化物歧化酶（SOD）-1和-2的表达。结果表明，在分泌中期发情期对猪子宫进行60分钟的局部缺血会导致HIF-1α表达降低以及SOD-2基因表达增加。SOD-2的较高表达表明该酶可能在抑制缺血性子宫内膜中HIF-1α的积累方面发挥重要作用。
