Sanchez Alejandro Martin, Franceschini Gianluca, Orlandi Armando, Di Leone Alba, Masetti Riccardo
Multidisciplinary Breast Center - Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
Unit of Clinical Oncology - Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
Surgeon. 2017 Dec;15(6):372-378. doi: 10.1016/j.surge.2017.05.006. Epub 2017 Jun 16.
The term "locally advanced breast cancer" (LABC) encompasses a heterogeneous group of breast neoplasms that represent an extremely variable percentage of newly diagnosed breast cancers (4-90%, depending of world regions). These cancers may have different clinical and biological characteristics that can be managed by primary surgery or neoadjuvant integrated treatments. In this paper we review the updated guidelines and discuss most recently reported evidence related to LABC multidisciplinary workout, in order to maximize results of combined systemic therapies, modern surgical procedures and radiotherapy.
“局部晚期乳腺癌”（LABC）这一术语涵盖了一组异质性的乳腺肿瘤，在新诊断的乳腺癌中所占比例差异极大（4% - 90%，因世界不同地区而异）。这些癌症可能具有不同的临床和生物学特征，可通过初次手术或新辅助综合治疗来处理。在本文中，我们回顾了最新指南，并讨论了与LABC多学科治疗相关的最新报道证据，以便最大限度地提高联合全身治疗、现代外科手术和放疗的效果。
