Melo-Bernal W, Chernov V, Chernov G, Barboza-Flores M
Departamento de Investigación en Física, Doctorado en Física Universidad de Sonora, 83000 Hermosillo, Sonora, México.
Departamento de Investigación en Física, Universidad de Sonora, 83000 Hermosillo, Sonora, México.
Appl Radiat Isot. 2018 Aug;138:50-55. doi: 10.1016/j.apradiso.2017.05.020. Epub 2017 May 31.
In this study, an analytical model for the assessment of the modification of cell culture survival under ionizing radiation assisted with nanoparticles (NPs) is presented. The model starts from the radial dose deposition around a single NP, which is used to describe the dose deposition in a cell structure with embedded NPs and, in turn, to evaluate the number of lesions formed by ionizing radiation. The model is applied to the calculation of relative biological effectiveness values for cells exposed to 0.5mg/g of uniformly dispersed NPs with a radius of 10nm made of Fe, I, Gd, Hf, Pt and Au and irradiated with X-rays of energies 20keV higher than the element K-shell binding energy.
在本研究中，提出了一种用于评估在纳米颗粒（NPs）辅助下电离辐射对细胞培养存活率影响的分析模型。该模型从单个NP周围的径向剂量沉积开始，用于描述含有嵌入NP的细胞结构中的剂量沉积，进而评估电离辐射形成的损伤数量。该模型用于计算暴露于0.5mg/g由Fe、I、Gd、Hf、Pt和Au制成的半径为10nm的均匀分散NP且用能量比元素K壳层结合能高20keV的X射线辐照的细胞的相对生物效能值。
