Physikalisch-Technische Bundesanstalt (PTB), 38116 Braunschweig, Germany. Author to whom any correspondence should be addressed.
Phys Med Biol. 2019 Aug 7;64(15):155016. doi: 10.1088/1361-6560/ab31d4.
Nanoparticles (NPs) containing high atomic number (high-Z) materials have been shown to enhance the radiobiological effectiveness of ionizing radiation. This effect is often attributed to an enhancement of the absorbed dose in the vicinity of the NPs, based on Monte Carlo simulations that show a significant local enhancement of the energy deposition on the microscopic scale. The results of such simulations may be significantly biased and lead to a severe overestimation of the dose enhancement if the condition of secondary particle equilibrium is not met in the simulation setup. This current work shows an approach to estimate a 'realistic' dose enhancement from the results of such biased simulations which is based on published photon interaction data and provides a way for correcting biased results.
纳米粒子（NPs）含有高原子序数（高 Z）材料已被证明可以提高电离辐射的生物辐射效应。这种效应通常归因于 NPs 附近吸收剂量的增加，基于蒙特卡罗模拟表明在微观尺度上能量沉积的显著局部增强。如果在模拟设置中未满足次级粒子平衡条件，则此类模拟的结果可能存在严重偏差，并导致剂量增强的严重高估。本研究提出了一种从有偏差的模拟结果中估计“实际”剂量增强的方法，该方法基于已发表的光子相互作用数据，并为纠正有偏差的结果提供了一种方法。
