Davis Carrie A, Seddighi Reza, Cox Sherry K, Sun Xiaocun, Egger Christine M, Doherty Thomas J
Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, TN, USA.
Department of Large Animal Clinical Sciences, University of Tennessee, Knoxville, TN, USA.
Vet Anaesth Analg. 2017 Jul;44(4):727-737. doi: 10.1016/j.vaa.2016.11.002. Epub 2017 Jan 11.
To determine the effect of fentanyl on the induction dose of propofol and minimum infusion rate required to prevent movement in response to noxious stimulation (MIR) in dogs.
Crossover experimental design.
Six healthy, adult intact male Beagle dogs, mean±standard deviation 12.6±0.4 kg.
Dogs were administered 0.9% saline (treatment P), fentanyl (5 μg kg) (treatment PLDF) or fentanyl (10 μg kg) (treatment PHDF) intravenously over 5 minutes. Five minutes later, anesthesia was induced with propofol (2 mg kg, followed by 1 mg kg every 15 seconds to achieve intubation) and maintained for 90 minutes by constant rate infusions (CRIs) of propofol alone or with fentanyl: P, propofol (0.5 mg kg minute); PLDF, propofol (0.35 mg kg minute) and fentanyl (0.1 μg kg minute); PHDF, propofol (0.3 mg kg minute) and fentanyl (0.2 μg kg minute). Propofol CRI was increased or decreased based on the response to stimulation (50 V, 50 Hz, 10 mA), with 20 minutes between adjustments. Data were analyzed using a mixed-model anova and presented as mean±standard error.
ropofol induction doses were 6.16±0.31, 3.67±0.21 and 3.33±0.42 mg kg for P, PLDF and PHDF, respectively. Doses for PLDF and PHDF were significantly decreased from P (p<0.05) but not different between treatments. Propofol MIR was 0.60±0.04, 0.29±0.02 and 0.22±0.02 mg kg minute for P, PLDF and PHDF, respectively. MIR in PLDF and PHDF was significantly decreased from P. MIR in PLDF and PHDF were not different, but their respective percent decreases of 51±3 and 63±2% differed (p=0.035).
Fentanyl, at the doses studied, caused statistically significant and clinically important decreases in the propofol induction dose and MIR.
确定芬太尼对犬丙泊酚诱导剂量及预防有害刺激反应性运动所需的最小输注速率（MIR）的影响。
交叉实验设计。
6只健康成年雄性比格犬，平均体重±标准差为12.6±0.4千克。
犬静脉内5分钟输注0.9%生理盐水（P组）、芬太尼（5μg/kg）（PLDF组）或芬太尼（10μg/kg）（PHDF组）。5分钟后，用丙泊酚诱导麻醉（2mg/kg，随后每15秒追加1mg/kg直至插管），并通过单独持续输注丙泊酚或联合芬太尼维持90分钟：P组，丙泊酚（0.5mg/kg·分钟）；PLDF组，丙泊酚（0.35mg/kg·分钟）和芬太尼（0.1μg/kg·分钟）；PHDF组，丙泊酚（0.3mg/kg·分钟）和芬太尼（0.2μg/kg·分钟）。根据刺激反应（50V，50Hz，10mA）调整丙泊酚持续输注速率，调整间隔为20分钟。数据采用混合模型方差分析，结果以平均值±标准误表示。
P组、PLDF组和PHDF组丙泊酚诱导剂量分别为6.16±0.31、3.67±0.21和3.33±0.42mg/kg。PLDF组和PHDF组的剂量较P组显著降低（p<0.05），但两组间无差异。P组、PLDF组和PHDF组丙泊酚MIR分别为0.60±0.04、0.29±0.02和0.22±0.02mg/kg·分钟。PLDF组和PHDF组的MIR较P组显著降低。PLDF组和PHDF组的MIR无差异，但各自降低百分比分别为51±3%和63±2%，存在差异（p=0.035）。
在所研究的剂量下，芬太尼使丙泊酚诱导剂量和MIR在统计学上有显著降低且具有临床重要意义。
