Gioeni Daniela, Brioschi Federica Alessandra, Di Cesare Federica, Rabbogliatti Vanessa, Amari Martina, Zanzani Sergio, Cagnardi Petra, Ravasio Giuliano
Department of Veterinary Medicine, Università degli Studi di Milano, 20122 Milan, Italy.
Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, 20122 Milan, Italy.
Animals (Basel). 2020 Nov 6;10(11):2057. doi: 10.3390/ani10112057.
The aim of this study was to compare the sedative and physiological effects following either oral transmucosal (OTM) or intramuscular administration of dexmedetomidine-methadone combination in healthy dogs. Thirty dogs were randomly assigned to receive a dexmedetomidine-methadone combination either by the OTM ( = 15) or intramuscular ( = 15) route. Sedation was scored 10, 20, and 30 min after drugs administration. Heart rate (HR), non-invasive blood pressure (NIBP), respiratory rate (f), and body rectal temperature were recorded before drugs administration and then every 10 min for 30 min. Propofol dose required for orotracheal intubation was recorded. Sedation scores increased over time within both groups with higher values in intramuscular group ( < 0.05). Within each group, HR decreased significantly compared with baseline < 0.001) and was significantly lower in intramuscular group compared with the OTM group ( < 0.001). In both groups, NIBP increased significantly compared with baseline ( < 0.05). In the intramuscular group, f was lower compared with the OTM group at all the observational time points ( < 0.001). Propofol dose was lower in the intramuscular group ( < 0.05). Compared to intramuscular dexmedetomidine-methadone, OTM combination produced lower but effective sedation in healthy dogs.
本研究的目的是比较健康犬经口腔黏膜（OTM）或肌肉注射右美托咪定-美沙酮联合用药后的镇静和生理效应。30只犬被随机分为两组，每组15只，分别经OTM或肌肉注射途径接受右美托咪定-美沙酮联合用药。给药后10、20和30分钟对镇静效果进行评分。在给药前记录心率（HR）、无创血压（NIBP）、呼吸频率（f）和直肠体温，然后在给药后的30分钟内每隔10分钟记录一次。记录气管插管所需的丙泊酚剂量。两组的镇静评分均随时间增加，肌肉注射组的值更高（P<0.05）。在每组中，与基线相比HR显著降低（P<0.001），且肌肉注射组的HR显著低于OTM组（P<0.001）。在两组中，与基线相比NIBP显著升高（P<0.05）。在所有观察时间点，肌肉注射组的f均低于OTM组（P<0.001）。肌肉注射组的丙泊酚剂量较低（P<0.05）。与肌肉注射右美托咪定-美沙酮相比，OTM联合用药在健康犬中产生的镇静作用较低但有效。
