Xia Jinggang, Xu Ji, Hu Shaodong, Hao Hengjian, Yin Chunlin, Xu Dong
Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Clin Chim Acta. 2017 Aug;471:196-200. doi: 10.1016/j.cca.2017.06.014. Epub 2017 Jun 15.
We explored the impact of glycemic variability on the occurrence of periprocedural myocardial infarction and major adverse cardiovascular events (MACE) after coronary intervention in patients with stable angina pectoris (SAP) at 6months follow-up.
From May 2015 to April 2016, a total of 746 patients with SAP were divided to high glycemic variability group (H group) (n=261) and low glycemic variability group (L group) (n=485). The primary end point was incidence of periprocedural myocardial infarction and MACE at 6months follow-up.
The occurrence of periprocedural myocardial infarction occurred in 18.8% of patients in H group and in 12.4% in L group (P=0.03). The incidence of MACE at 6months follow-up was 9.6% in H group and 4.5% in L group (P=0.01). Multivariable analysis suggested that high glycemic variability conferred a 53% risk increment of 6months follow-up MACE (odds ratio 2.13, 95% confidence interval 1.85-5.38; P=0.01).
The trial shows that higher blood glucose variability was correlated with higher incidence of periprocedural myocardial infarction and MACE at 6months follow-up.
我们探讨了血糖变异性对稳定型心绞痛（SAP）患者冠状动脉介入治疗后6个月随访期间围手术期心肌梗死和主要不良心血管事件（MACE）发生情况的影响。
2015年5月至2016年4月，共746例SAP患者被分为高血糖变异性组（H组）（n = 261）和低血糖变异性组（L组）（n = 485）。主要终点是6个月随访时围手术期心肌梗死和MACE的发生率。
H组患者围手术期心肌梗死发生率为18.8%，L组为12.4%（P = 0.03）。H组6个月随访时MACE发生率为9.6%，L组为4.5%（P = 0.01）。多变量分析表明，高血糖变异性使6个月随访时MACE风险增加53%（比值比2.13，95%置信区间1.85 - 5.38；P = 0.01）。
该试验表明，较高的血糖变异性与6个月随访时较高的围手术期心肌梗死和MACE发生率相关。
