• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胰腺导管腺癌异种移植瘤的淋巴结转移与理化微环境

Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts.

作者信息

Andersen Lise Mari K, Wegner Catherine S, Simonsen Trude G, Huang Ruixia, Gaustad Jon-Vidar, Hauge Anette, Galappathi Kanthi, Rofstad Einar K

机构信息

Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

出版信息

Oncotarget. 2017 Jul 18;8(29):48060-48074. doi: 10.18632/oncotarget.18231.

DOI:10.18632/oncotarget.18231
PMID:28624797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5564626/
Abstract

Pancreatic ductal adenocarcinoma (PDAC) patients develop lymph node metastases early and have a particularly poor prognosis. The poor prognosis has been shown to be associated with the physicochemical microenvironment of the tumor tissue, which is characterized by desmoplasia, abnormal microvasculature, extensive hypoxia, and highly elevated interstitial fluid pressure (IFP). In this study, we searched for associations between lymph node metastasis and features of the physicochemical microenvironment in an attempt to identify mechanisms leading to metastatic dissemination and growth. BxPC-3 and Capan-2 PDAC xenografts were used as preclinical models of human PDAC. In both models, lymph node metastasis was associated with high IFP rather than high fraction of hypoxic tissue or high microvascular density. Seven angiogenesis-related genes associated with high IFP-associated lymph node metastasis were detected by quantitative PCR in each of the models, and these genes were all up-regulated in high IFP/highly metastatic tumors. Three genes were mutual for the BxPC-3 and Capan-2 models: transforming growth factor beta, angiogenin, and insulin-like growth factor 1. Further comprehensive studies are needed to determine whether there is a causal relationship between the up-regulation of these genes and high IFP and/or high propensity for lymph node metastasis in PDAC.

摘要

胰腺导管腺癌（PDAC）患者早期就会发生淋巴结转移，预后特别差。研究表明，这种不良预后与肿瘤组织的物理化学微环境有关，其特征为纤维组织增生、微血管异常、广泛缺氧以及间质液压力（IFP）高度升高。在本研究中，我们探寻淋巴结转移与物理化学微环境特征之间的关联，试图确定导致转移扩散和生长的机制。BxPC-3和Capan-2 PDAC异种移植瘤被用作人类PDAC的临床前模型。在这两种模型中，淋巴结转移均与高IFP相关，而非与缺氧组织的高比例或高微血管密度相关。通过定量PCR在每个模型中检测到七个与高IFP相关的淋巴结转移有关的血管生成相关基因，并且这些基因在高IFP/高转移性肿瘤中均上调。三个基因在BxPC-3和Capan-2模型中是共同的：转化生长因子β、血管生成素和胰岛素样生长因子1。需要进一步进行全面研究，以确定这些基因的上调与PDAC中高IFP和/或高淋巴结转移倾向之间是否存在因果关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/345cb6ab4489/oncotarget-08-48060-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/e1fea55fd9e8/oncotarget-08-48060-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/7ee6915761d3/oncotarget-08-48060-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/72f57d29c9b5/oncotarget-08-48060-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/fe71f03d0410/oncotarget-08-48060-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/ae4baf88d1d0/oncotarget-08-48060-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/39b1d59d4c14/oncotarget-08-48060-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/345cb6ab4489/oncotarget-08-48060-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/e1fea55fd9e8/oncotarget-08-48060-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/7ee6915761d3/oncotarget-08-48060-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/72f57d29c9b5/oncotarget-08-48060-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/fe71f03d0410/oncotarget-08-48060-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/ae4baf88d1d0/oncotarget-08-48060-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/39b1d59d4c14/oncotarget-08-48060-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/134d/5564626/345cb6ab4489/oncotarget-08-48060-g007.jpg

相似文献

1
Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts.胰腺导管腺癌异种移植瘤的淋巴结转移与理化微环境
Oncotarget. 2017 Jul 18;8(29):48060-48074. doi: 10.18632/oncotarget.18231.
2
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts.胰腺腺癌异种移植瘤微环境的动态对比增强磁共振成像
Acta Oncol. 2017 Dec;56(12):1754-1762. doi: 10.1080/0284186X.2017.1343494. Epub 2017 Jun 29.
3
DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts.索坦诱导的肿瘤微血管和缺氧变化的 DCE-MRI：胰腺导管腺癌异种移植的研究。
Neoplasia. 2018 Jul;20(7):734-744. doi: 10.1016/j.neo.2018.05.006. Epub 2018 Jun 19.
4
The microRNA-218 and ROBO-1 signaling axis correlates with the lymphatic metastasis of pancreatic cancer.miRNA-218 和 ROBO-1 信号轴与胰腺癌的淋巴转移相关。
Oncol Rep. 2013 Aug;30(2):651-8. doi: 10.3892/or.2013.2516. Epub 2013 Jun 3.
5
Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts.人黑色素瘤异种移植物的转移途径和微血管及理化微环境。
J Transl Med. 2017 Oct 10;15(1):203. doi: 10.1186/s12967-017-1307-4.
6
Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma.CCR7 表达缺失是胰腺导管腺癌淋巴扩散的限制因素。
Int J Cancer. 2012 Aug 15;131(4):E371-81. doi: 10.1002/ijc.26502. Epub 2012 Jan 11.
7
Tumor interstitial fluid pressure-a link between tumor hypoxia, microvascular density, and lymph node metastasis.肿瘤间质液压力——肿瘤缺氧、微血管密度与淋巴结转移之间的联系
Neoplasia. 2014 Jul;16(7):586-94. doi: 10.1016/j.neo.2014.07.003.
8
Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer.血管内皮生长因子-D在胰腺导管癌模型中诱导淋巴管生成和淋巴转移。
Int J Oncol. 2005 Sep;27(3):669-79.
9
Glypican-3 and KRT19 are markers associating with metastasis and poor prognosis of pancreatic ductal adenocarcinoma.磷脂酰肌醇蛋白聚糖-3和细胞角蛋白19是与胰腺导管腺癌转移及预后不良相关的标志物。
Cancer Biomark. 2016;17(4):397-404. doi: 10.3233/CBM-160655.
10
Desmoplasia in Lymph Node Metastasis of Pancreatic Adenocarcinoma Reveals Activation of Cancer-Associated Fibroblasts Pattern and T-helper 2 Immune Cell Infiltration.胰腺腺癌淋巴结转移中的促纤维增生反应显示癌症相关成纤维细胞模式的激活和辅助性T细胞2免疫细胞浸润。
Pancreas. 2019 Mar;48(3):367-373. doi: 10.1097/MPA.0000000000001261.

引用本文的文献

1
Vascular regional analysis unveils differential responses to anti-angiogenic therapy in pancreatic xenografts through macroscopic photoacoustic imaging.血管区域分析通过宏观光声成像揭示了胰腺异种移植瘤对抗血管生成治疗的不同反应。
Theranostics. 2025 Jan 27;15(6):2649-2671. doi: 10.7150/thno.99361. eCollection 2025.
2
Predictive Design and Analysis of Drug Transport by Multiscale Computational Models Under Uncertainty.多尺度计算模型在不确定性下的药物传输预测设计与分析。
Pharm Res. 2023 Feb;40(2):501-523. doi: 10.1007/s11095-022-03298-8. Epub 2022 Jun 1.
3
Assessment of Intratumor Heterogeneity in Parametric Dynamic Contrast-Enhanced MR Images: A Comparative Study of Novel and Established Methods.

本文引用的文献

1
Functional intratumoral lymphatics in patient-derived xenograft models of squamous cell carcinoma of the uterine cervix: implications for lymph node metastasis.子宫颈鳞状细胞癌患者来源异种移植模型中的功能性肿瘤内淋巴管：对淋巴结转移的影响
Oncotarget. 2016 Aug 30;7(35):56986-56997. doi: 10.18632/oncotarget.10931.
2
Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue.胰腺导管腺癌中的血管生成：一个有争议的问题。
Oncotarget. 2016 Sep 6;7(36):58649-58658. doi: 10.18632/oncotarget.10765.
3
Pancreatic cancer biology and genetics from an evolutionary perspective.
参数动态对比增强磁共振图像中肿瘤内异质性的评估：新方法与既定方法的比较研究
Front Oncol. 2021 Sep 21;11:722773. doi: 10.3389/fonc.2021.722773. eCollection 2021.
4
Collective tumor cell migration in the presence of fibroblasts.成纤维细胞存在下的肿瘤细胞集体迁移。
J Biomech. 2020 Feb 13;100:109568. doi: 10.1016/j.jbiomech.2019.109568. Epub 2019 Dec 19.
5
Intratumor Heterogeneity in Interstitial Fluid Pressure in Cervical and Pancreatic Carcinoma Xenografts.宫颈癌和胰腺癌异种移植瘤间质液压力的肿瘤内异质性
Transl Oncol. 2019 Aug;12(8):1079-1085. doi: 10.1016/j.tranon.2019.05.012. Epub 2019 Jun 4.
6
DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts.索坦诱导的肿瘤微血管和缺氧变化的 DCE-MRI：胰腺导管腺癌异种移植的研究。
Neoplasia. 2018 Jul;20(7):734-744. doi: 10.1016/j.neo.2018.05.006. Epub 2018 Jun 19.
7
Increasing aggressiveness of patient-derived xenograft models of cervix carcinoma during serial transplantation.宫颈癌患者来源异种移植模型在连续传代移植过程中侵袭性增加。
Oncotarget. 2018 Apr 20;9(30):21036-21051. doi: 10.18632/oncotarget.24783.
8
Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts.人黑色素瘤异种移植物的转移途径和微血管及理化微环境。
J Transl Med. 2017 Oct 10;15(1):203. doi: 10.1186/s12967-017-1307-4.
从进化角度看胰腺癌生物学与遗传学
Nat Rev Cancer. 2016 Sep;16(9):553-65. doi: 10.1038/nrc.2016.66. Epub 2016 Jul 22.
4
Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content.胰腺腺癌异种移植瘤的扩散加权及动态对比增强MRI：与肿瘤分化及胶原含量的相关性
J Transl Med. 2016 Jun 7;14(1):161. doi: 10.1186/s12967-016-0920-y.
5
Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase.胰腺导管腺癌中的间质压力主要由凝胶-流体相主导。
Biophys J. 2016 May 10;110(9):2106-19. doi: 10.1016/j.bpj.2016.03.040.
6
Pathophysiological Basis for the Formation of the Tumor Microenvironment.肿瘤微环境形成的病理生理基础。
Front Oncol. 2016 Apr 12;6:66. doi: 10.3389/fonc.2016.00066. eCollection 2016.
7
TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway.肿瘤坏死因子-α通过ERK1/2/AP-1/VEGF-D通路促进胆囊癌的淋巴管生成和淋巴转移。
BMC Cancer. 2016 Mar 19;16:240. doi: 10.1186/s12885-016-2259-4.
8
The lymphatic system and pancreatic cancer.淋巴系统与胰腺癌
Cancer Lett. 2016 Oct 10;381(1):217-36. doi: 10.1016/j.canlet.2015.11.048. Epub 2015 Dec 29.
9
Overview of pre-clinical and clinical studies targeting angiogenesis in pancreatic ductal adenocarcinoma.针对胰腺导管腺癌血管生成的临床前和临床研究综述。
Cancer Lett. 2016 Oct 10;381(1):201-10. doi: 10.1016/j.canlet.2015.11.047. Epub 2015 Dec 23.
10
Analysis of the intra- and intertumoral heterogeneity of hypoxia in pancreatic cancer patients receiving the nitroimidazole tracer pimonidazole.接受硝基咪唑示踪剂匹莫硝唑的胰腺癌患者缺氧的瘤内和瘤间异质性分析
Br J Cancer. 2015 Sep 15;113(6):864-71. doi: 10.1038/bjc.2015.284. Epub 2015 Sep 1.