Department of Immunobiology and the Arizona Center on Aging, College of Medicine, University of Arizona, Tucson, AZ, 85724, USA.
The BIO5 Institute, University of Arizona, Tucson, AZ, USA.
Geroscience. 2017 Jun;39(3):245-249. doi: 10.1007/s11357-017-9984-8. Epub 2017 Jun 17.
Cytomegalovirus (CMV) is one of the most complex and most ubiquitous latent persistent viruses, with a considerable ability to evade and manipulate the immune system. Following an early-life infection, most immunocompetent humans spend several decades living with CMV, and, because the virus in these hosts does not cause manifest disease, CMV can be considered part of normal aging for more than half of humanity. However, there is accumulating evidence that CMV carriage is not a null event and that both potentially harmful and potentially beneficial outcomes emanate from the interaction of CMV with its mammalian hosts. This article provides an overview of the 6th International Workshop on CMV and Immunosenescence, highlighting the advances in the field made in the past two years, as related to CMV epidemiology/geroscience, CMV virology with an accent on latency, and CMV immune evasion and immune recognition of the virus and its antigens.
巨细胞病毒（CMV）是最复杂和最普遍的潜伏性持续性病毒之一，具有相当大的逃避和操纵免疫系统的能力。在生命早期感染后，大多数免疫功能正常的人会在数十年的时间里携带 CMV，由于这些宿主中的病毒不会引起明显的疾病，因此 CMV 可以被认为是超过一半人类正常衰老的一部分。然而，越来越多的证据表明，CMV 携带并不是一个无足轻重的事件，CMV 与其哺乳动物宿主的相互作用会产生潜在有害和潜在有益的结果。本文概述了第六届国际 CMV 与免疫衰老研讨会，重点介绍了过去两年中该领域的进展，包括 CMV 流行病学/老年科学、CMV 病毒学（重点是潜伏期）以及 CMV 免疫逃逸和对病毒及其抗原的免疫识别。
