在体弱的晚期老年患者中使用琥珀酸西苯唑啉诱发低血糖昏迷
Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects.
作者信息
Hirata Yurie, Kamei Shinji, Tatsumi Fuminori, Shimoda Masashi, Tanabe Akihito, Sanada Junpei, Fushimi Yoshiro, Irie Shintaro, Mune Tomoatsu, Kaku Kohei, Kaneto Hideaki
机构信息
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
出版信息
Intern Med. 2017;56(12):1527-1529. doi: 10.2169/internalmedicine.56.8120. Epub 2017 Jun 15.
Succinic acid cibenzoline (CZ) is an antiarrhythmic agent often used for the treatment of tachyarrhythmia. However, hypoglycemia should be avoided in the treatment of diabetes. We herein report two late-stage elderly subjects who experienced a severe and prolonged hypoglycemic coma after the usage of CZ. These cases suggest that, when CZ is administered to elderly subjects with renal dysfunction and/or frailty, we should be aware of the possibility that this medicine may induce hypoglycemia and should adjust the dose as appropriate and monitor the concentration of CZ to avoid severe hypoglycemia.
琥珀酸西苯唑啉（CZ）是一种常用于治疗快速性心律失常的抗心律失常药物。然而，糖尿病治疗中应避免低血糖。我们在此报告两例老年晚期患者，他们在使用CZ后发生了严重且持续时间较长的低血糖昏迷。这些病例提示，当给肾功能不全和/或身体虚弱的老年患者使用CZ时，我们应意识到这种药物可能诱发低血糖的可能性，应适当调整剂量并监测CZ浓度以避免严重低血糖。
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