[老年人中昔苯唑啉诱发的低血糖症]

[Hypoglycemia induced by cibenzoline in the elderly].

作者信息

Houdent C, Noblet C, Vandoren C, Levesque H, Morin C, Moore N, Courtois H, Wolf L M

机构信息

Clinique Médicale B, CHRU de ROUEN, Hôpital de Bois-Guillaume.

出版信息

Rev Med Interne. 1991 Mar-Apr;12(2):143-5. doi: 10.1016/s0248-8663(05)81379-7.

DOI:10.1016/s0248-8663(05)81379-7

PMID:1852997

Abstract

Hypoglycaemia induced by class IA antiarrhythmic agents has been described. A case of cibenzoline-induced hypoglycaemia with favourable outcome is reported. The patient's age (84 years), increased renal impairment and malnutrition acted as facilitating factors. Blood insulin levels were normal in both absolute and relative values. Therapeutic overdosage in relation to age and renal function has been found in 20 out of 24 cases published or recorded by the French pharmacovigilance system. The mechanism of this hypoglycaemia is uncertain; absolute or relative hyperinsulinism has been detected in only 5 out of 14 controlled cases.

摘要

已有关于IA类抗心律失常药物诱发低血糖的报道。本文报告了1例西苯唑啉诱发低血糖且预后良好的病例。患者年龄（84岁）、肾功能损害加重及营养不良均为促成因素。患者血液胰岛素水平的绝对值和相对值均正常。法国药物警戒系统公布或记录的24例病例中，有20例发现存在与年龄和肾功能相关的治疗用药过量情况。这种低血糖的机制尚不确定；在14例对照病例中，仅5例检测到绝对或相对高胰岛素血症。