Rohban Rokhsareh, Prietl Barbara, Pieber Thomas R
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Center for Medical Research (ZMF), Medical University of Graz, Graz, Austria.
Transfus Med Hemother. 2017 Jun;44(3):174-182. doi: 10.1159/000477677. Epub 2017 Jun 6.
The cellular components and molecular processes of signaling during vasculogenesis have been investigated for decades. Considerable efforts have been made to unravel regulatory mechanisms of vasculogenesis through crosstalk between vasculogenic playmakers located in the vascular niche, namely hematopoietic stem cells, endothelial progenitor cells, and mesenchymal stem and progenitor cells. Recent studies have increased the knowledge about signaling events within vascular microenvironment that leads to vasculogenesis. Findings from these recent studies indicate the impact of cellular crosstalk through signaling pathways such as vascular endothelial growth factor signaling, wingless and Notch signaling in vasculogenesis and vascular development. In this review, we highlight the signaling signature between stem and progenitor cellular mediators during vasculogenesis. We further focus on hematopoietic stem cell-endothelial progenitor cell crosstalk during vasculogenesis and discuss their potential implications and benefits for therapeutic interventions and regenerative therapy.
数十年来，人们一直在研究血管生成过程中信号传导的细胞成分和分子过程。为了通过位于血管龛中的血管生成参与者（即造血干细胞、内皮祖细胞以及间充质干/祖细胞）之间的相互作用来阐明血管生成的调控机制，已经付出了巨大努力。最近的研究增加了我们对导致血管生成的血管微环境中信号事件的了解。这些最新研究的结果表明，细胞间通过血管内皮生长因子信号传导、无翅型和Notch信号传导等信号通路相互作用，对血管生成和血管发育产生影响。在这篇综述中，我们重点介绍血管生成过程中干细胞和祖细胞介质之间的信号特征。我们进一步关注血管生成过程中造血干细胞与内皮祖细胞之间的相互作用，并讨论它们在治疗干预和再生治疗中的潜在意义和益处。
