Johnson Brandy J, Malanoski Anthony P, Erickson Jeffrey S, Liu Ray, Remenapp Allison R, Stenger David A, Moore Martin H
Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375 USA.
Thomas Jefferson High School for Science and Technology, Alexandria, VA 22312 USA.
Heliyon. 2017 Jun 7;3(6):e00312. doi: 10.1016/j.heliyon.2017.e00312. eCollection 2017 Jun.
Here, the potential of colorimetric sensors utilizing porphyrin indicators for long term environmental monitoring is demonstrated. Prototype devices based on commercial color sensing chips (six per device) were combined with in-house developed algorithms for data analysis. The devices are intended to provide real-time sensing of threats. An initial outdoor data set was collected using prototype devices with occasional spiked exposure to targets. This data was supported by similar data collected in a controlled indoor environment. Weaknesses in the noted performance of the devices during these experiments were addressed through altering device parameters, algorithm parameters, and array element composition. Additional outdoor data sets totaling 1,616 h and indoor data sets totaling 728 h were collected in support of assessing these changes to the system configuration. The optimized system provided receiver operating characteristics (ROC) of specificity 0.97 and sensitivity 1.0.
在此，展示了利用卟啉指示剂的比色传感器用于长期环境监测的潜力。基于商用颜色传感芯片（每个设备六个）的原型设备与内部开发的数据分析算法相结合。这些设备旨在提供对威胁的实时传感。使用原型设备收集了初始室外数据集，偶尔对目标进行加标暴露。该数据得到了在受控室内环境中收集的类似数据的支持。通过改变设备参数、算法参数和阵列元件组成，解决了这些实验中设备性能的不足之处。为了评估对系统配置的这些更改，又收集了总计1616小时的额外室外数据集和总计728小时的室内数据集。优化后的系统提供了特异性为0.97、灵敏度为1.0的接收器操作特性（ROC）。
