a Department of Environmental Science , Zhejiang University , Hangzhou , China.
b Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control , Zhejiang University , Hangzhou , China.
Nanotoxicology. 2017 Jun;11(5):591-612. doi: 10.1080/17435390.2017.1343404.
With their growing production and application, engineered nanoparticles (NPs) are increasingly discharged into the environment. The released NPs can potentially interact with pre-existing contaminants, leading to biological effects (bioaccumulation and/or toxicity) that are poorly understood. Most studies on NPs focus on single analyte exposure; the existing literature on joint toxicity of NPs and co-existing contaminants is rather limited but beginning to develop rapidly. This is the first review paper evaluating the current state of knowledge regarding the joint effects of NPs and co-contaminants. Here, we review: (1) methods for investigating and evaluating joint effects of NPs and co-contaminants; (2) simultaneous toxicities from NPs co-exposed with organic contaminants, metal/metalloid ions, dissolved organic matter (DOM), inorganic ligands and additional NPs; and (3) the influence of NPs co-exposure on the bioaccumulation of organic contaminants and heavy metal ions, as well as the influence of contaminants on NPs bioaccumulation. In addition, future research needs are discussed so as to better understand risk associated with NPs-contaminant co-exposure.
随着工程纳米粒子（NPs）的产量和应用不断增加，它们越来越多地被排放到环境中。释放的 NPs 可能与已存在的污染物相互作用，导致生物效应（生物积累和/或毒性），而这些生物效应目前了解甚少。大多数关于 NPs 的研究都集中在单一分析物暴露上；关于 NPs 和共存污染物联合毒性的现有文献相当有限，但正在迅速发展。这是第一篇评估关于 NPs 和共存污染物联合效应的现有知识状况的综述论文。在这里，我们回顾了：（1）研究和评估 NPs 和共存污染物联合效应的方法；（2）NPs 与有机污染物、金属/类金属离子、溶解有机物 (DOM)、无机配体和其他 NPs 同时暴露的毒性；以及（3）NPs 共同暴露对有机污染物和重金属离子生物积累的影响，以及污染物对 NPs 生物积累的影响。此外，还讨论了未来的研究需求，以便更好地了解与 NPs-污染物共同暴露相关的风险。
