Tyliszczak Bożena, Drabczyk Anna, Kudłacik-Kramarczyk Sonia, Sobczak-Kupiec Agnieszka
a Department of Chemistry and Technology of Polymers , Cracow University of Technology , Krakow , Poland.
b Institute of Inorganic Chemistry and Technology, Cracow University of Technology , Krakow , Poland.
J Biomater Sci Polym Ed. 2017 Oct;28(15):1665-1676. doi: 10.1080/09205063.2017.1344116. Epub 2017 Jun 26.
Hydrogels, chitosan as well as silver nanoparticles become in recent years materials characterized by a great interest. In present paper hydrogel based on chitosan and containing mentioned type of nano-sized particles have been synthesized by means of photopolymerization. Sorption capacity in selected liquids as well as behavior in simulated body fluid (such as Ringer's liquid) have been determined. Particularly attention was paid to the studies on toxicity of the hydrogels in relation to the epidermal cells as well as on their impact on growth of selected strain of bacteria (Escherichia coli). Furthermore, impact of introduction of nanosilver into hydrogel matrix on its properties has also been defined. Surface morphology of attained hydrogels by means of SEM analysis and chemical structure using spectroscopy have been checked. The most interesting conclusion is the fact that proposed chitosan based hydrogels modified with nanosilver do not affect negatively on epidermal cells. However, they inhibit a growth of E. coli. These two observations make them very interesting from the medical point of view.
水凝胶、壳聚糖以及银纳米颗粒近年来成为备受关注的材料。在本文中，通过光聚合反应合成了基于壳聚糖并含有上述纳米级颗粒类型的水凝胶。测定了其在选定液体中的吸附能力以及在模拟体液（如林格氏液）中的行为。特别关注了水凝胶对表皮细胞的毒性研究以及对选定细菌菌株（大肠杆菌）生长的影响。此外，还确定了将纳米银引入水凝胶基质对其性能的影响。通过扫描电子显微镜（SEM）分析检查了所得水凝胶的表面形态，并使用光谱学分析了其化学结构。最有趣的结论是，用纳米银改性的基于壳聚糖的水凝胶对表皮细胞没有负面影响。然而，它们会抑制大肠杆菌的生长。从医学角度来看，这两个观察结果使它们非常有趣。
