OIE Rabies Reference Laboratory, ARC-Onderstepoort Veterinary Institute (ARC-OVI), Onderstepoort, South Africa; Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, South Africa.
ANSES, Nancy Laboratory for Rabies and Wildlife, OIE and EU Rabies Reference Laboratory, WHO Collaborative Center for Research and Management in Zoonoses Control, Malzéville, France.
Microbes Infect. 2017 Sep-Oct;19(9-10):485-491. doi: 10.1016/j.micinf.2017.05.005. Epub 2017 Jun 13.
Rabies is a fatal zoonotic disease and infections generally lead to a fatal encephalomyelitis in both humans and animals. In South Africa, domestic (dogs) and the wildlife (yellow mongoose) host species maintain the canid and mongoose rabies variants respectively. In this study, pathogenicity differences of South African canid and mongoose rabies viruses were investigated in a murine model, by assessing the progression of clinical signs and survivorship. Comparison of glycoprotein gene sequences revealed amino acid differences that may underpin the observed pathogenicity differences. Cumulatively, our results suggest that the canid rabies virus may be more neurovirulent in mice than the mongoose rabies variant.
狂犬病是一种致命的人畜共患病，感染通常会导致人和动物的致命性脑脊髓炎。在南非，犬科动物（狗）和野生生物（黄貂鱼）宿主分别维持着犬科和貂科狂犬病变种。在这项研究中，通过评估临床症状和存活率，在小鼠模型中研究了南非犬科和貂科狂犬病病毒的致病性差异。比较糖蛋白基因序列显示，氨基酸差异可能是观察到的致病性差异的基础。总的来说，我们的结果表明，犬科狂犬病病毒在小鼠中的神经毒力可能比貂科狂犬病变种更强。
