Duan Honglei, Zhao Guangfeng, Xu Biyun, Hu Suwei, Li Jie
Clin Lab. 2017 May 1;63(5):921-925. doi: 10.7754/Clin.Lab.2016.161103.
Identifying women at risk of preeclampsia (PE) by maternal serum screening is conducive to prompt gestational management and thereby improve both maternal and perinatal outcomes. The purpose of the present study was to evaluate the association between the concentrations of maternal serum placental growth factor (PLGF), pregnancy associated plasma protein-A (PAPPA), free β-human chorionic gonadotropin (β-hCG), and αFetoprotein (AFP) and the development of preeclampsia early in the second trimester.
Forty pregnant women subsequently developed mild PE, 21 pregnant women subsequently developed severe PE, and 61 cases of normotensive controls were included. Maternal serum concentrations of PLGF, PAPPA, β-hCG, and AFP were measured at 15 - 20 weeks of gestation.
Serum PLGF level was lower in women who subsequently developed PE than in normotensive controls. However, the significant difference was only found between the severe PE and control groups (p = 0.015). Serum PAPPA, β-hCG, and AFP levels were not significantly different between the PE and control groups.
Serum PLGF level was lower in women who subsequently developed severe PE early in the second trimester, suggesting its role in prediction of PE.
通过母体血清筛查识别先兆子痫（PE）风险女性有利于及时进行孕期管理，从而改善孕产妇和围产儿结局。本研究的目的是评估孕中期早期母体血清胎盘生长因子（PLGF）、妊娠相关血浆蛋白-A（PAPPA）、游离β-人绒毛膜促性腺激素（β-hCG）和甲胎蛋白（AFP）浓度与先兆子痫发生之间的关联。
纳入40例随后发生轻度PE的孕妇、21例随后发生重度PE的孕妇以及61例血压正常的对照组。在妊娠15-20周时测量母体血清中PLGF、PAPPA、β-hCG和AFP的浓度。
随后发生PE的女性血清PLGF水平低于血压正常的对照组。然而，仅在重度PE组和对照组之间发现显著差异（p = 0.015）。PE组和对照组之间血清PAPPA、β-hCG和AFP水平无显著差异。
孕中期早期随后发生重度PE的女性血清PLGF水平较低，提示其在PE预测中的作用。
