由N-炔丙基β-烯胺酮经碱催化级联合成2,3-二氢呋喃并[2,3-b]吡啶和2,3-二氢-1H-吡咯并[2,3-b]吡啶。
Base-catalyzed cascade synthesis of 2,3-dihydrofuro[2,3-b]pyridines and 2,3-dihydro-1H-pyrrolo[2,3-b]pyridines from N-propargylic β-enaminones.
作者信息
Yang Xiaobing, Hu Fangzhong, Wang Yang, Yang Chiming, Zou Xiaomao, Liu Jiahui, Zhang Qichun
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.
出版信息
Chem Commun (Camb). 2017 Jul 4;53(54):7497-7500. doi: 10.1039/c7cc03308g.
PMID:28628175
Abstract
A novel protocol to prepare multi-substituted dihydrofuropyridine and dihydropyrrolopyridine derivatives from KOH-catalyzed reactions between readily available N-propargylic β-enaminones and arylaldehydes or N-sulfonyl imines has been developed in moderate to good yields.
摘要
已开发出一种新方法，通过在氢氧化钾催化下，使易得的N-炔丙基β-烯胺酮与芳醛或N-磺酰基亚胺反应，制备多取代二氢呋喃并吡啶和二氢吡咯并吡啶衍生物，产率中等至良好。
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